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Article

Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial

1
Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino City 275-0026, Japan
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Department of Rehabilitation Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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Department of Rehabilitation Medicine, Hatsudai Rehabilitation Hospital, 3-53-3 Honmachi, Shibuya-ku, Tokyo 151-0071, Japan
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Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan
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R & D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City 252-8583, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Maria Luz Fernandez and Andrea Fabbri
Nutrients 2022, 14(3), 685; https://doi.org/10.3390/nu14030685
Received: 14 December 2021 / Revised: 2 February 2022 / Accepted: 4 February 2022 / Published: 6 February 2022
(This article belongs to the Topic Applied Sciences in Functional Foods)
In post-stroke hemiparesis patients, the skeletal muscle mass decrease rapidly with the histological degradation. We investigated the effect of nutritional supplementation with whey protein and vitamin D on the muscle mass and muscle quality, in post-stroke convalescent rehabilitation patients in a randomized, single-blinded, placebo-controlled trial. Fifty patients were randomly assigned to two groups; HP group received supplemental jelly (100 kcal; whey protein 10 g; vitamin D 20 μg) twice a day throughout up to 16-week period, the control group received placebo jelly. Cross-sectional area (CSA) of thigh muscle, skeletal muscle index (SMI), muscle strength, activity of daily living (ADL), and some nutritional indicators in blood were measured. Although no significant difference was observed in CSA and SMI between the groups, fat infiltration into the thighs muscle was singnificantly lower in the HP group. There were no significant difference in muscle strength and ADL between the groups. Blood urea nitrogen and serum 25(OH)D at endpoint were significantly higher in the HP group but physiological normal ranges. Supplementation with whey protein and vitamin D in post-stroke patients led to suppression of fat infiltration into the muscle. Long-term follow-up studies are needed to verify whether this nutritional intervention provides substantial benefits for the prognosis of stroke survivors. View Full-Text
Keywords: stroke; sarcopenia; rehabilitation; whey protein; vitamin D stroke; sarcopenia; rehabilitation; whey protein; vitamin D
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MDPI and ACS Style

Honaga, K.; Mori, N.; Akimoto, T.; Tsujikawa, M.; Kawakami, M.; Okamoto, T.; Sakata, Y.; Hamano, H.; Takeda, Y.; Kondo, K. Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial. Nutrients 2022, 14, 685. https://doi.org/10.3390/nu14030685

AMA Style

Honaga K, Mori N, Akimoto T, Tsujikawa M, Kawakami M, Okamoto T, Sakata Y, Hamano H, Takeda Y, Kondo K. Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial. Nutrients. 2022; 14(3):685. https://doi.org/10.3390/nu14030685

Chicago/Turabian Style

Honaga, Kaoru, Naoki Mori, Tomonori Akimoto, Masahiro Tsujikawa, Michiyuki Kawakami, Tomoyuki Okamoto, Yasuyuki Sakata, Hirokazu Hamano, Yasuhiro Takeda, and Kunitsugu Kondo. 2022. "Investigation of the Effect of Nutritional Supplementation with Whey Protein and Vitamin D on Muscle Mass and Muscle Quality in Subacute Post-Stroke Rehabilitation Patients: A Randomized, Single-Blinded, Placebo-Controlled Trial" Nutrients 14, no. 3: 685. https://doi.org/10.3390/nu14030685

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