Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

Round 1

Reviewer 1 Report

This is an interesting review about the neuroprotective properties of quercetin a well known natural compound belonging to the family of flavonoids. The review is well written and well organized.  I recommend authors may address the following minor issues:

Page 2, lines 80. The authors state that flavonoids may be present as glycosylated substituents. I think worthy, to ensure a deeper coverage of the field, to underline that sugar derivatives of flavonoids may be prepared as prodrug delivery systems (see e.g ACS Chem Neurosci. 11, 2566, 2020). I suggest to mention this important note to the introduction. 

Author Response

Dear 

We are thankful for your comments on our manuscript entitled “Quercetin is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1”. We have revised our manuscript as you suggested and the relevant article has been cited, 

Sincerely yours

Prof. Beong Ou Lim
Department of Applied Life Science

Graduate School of Konkuk University

Reviewer 2 Report

The paper is interesting and give new information about maltol.

However, major revision is needed before the publication.

An English and typing revision is needed.

In addition:

- As about maltol identification, m/z 127.4 does not correspond to the deprotonated ion, but to protonated ion. In addition no data about the fragmentation are reported. They could help in the identification. NMR data are lacking, but they should be reported.

- It is not clear if the authors used maltol (isolated from red gingseng) or the red gingseng esxtrat. If they used the isolated maltol, how did they perform the preparative separation? What were the conditions applied?

- Why did the authors used Silymarin to compare the effect of maltol on body weight and organ index?

Author Response

Dear Editor

We would like to thank you for reviewing our manuscript. Reviewer 2 comments are not relevant to our manuscript. Our manuscript focuses on Quercetin against NDDs by alleviating oxidative stress. Hence, the reviewer's comment on mannitol.

Sincerely yours

Prof. Beong Ou Lim
Department of Applied Life Science.

Graduate School of Konkuk University

Round 2

Reviewer 2 Report

Graphical abstract should not be cited in the Introduction section. The use of this abstract is different. Please, see the instruction for the Authors.