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Nutrients
Volume 14
Issue 21
10.3390/nu14214628
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Article

Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation

by
Giusy Rita Caponio
1,†,
Giuseppe Celano
2,†,
Francesco Maria Calabrese
2,
Giuseppe Riezzo
1,
Antonella Orlando
1,
Benedetta D’Attoma
1,
Antonia Ignazzi
1,
Mirco Vacca
2,
Annalisa Porrelli
2,
Valeria Tutino
1,
Maria De Angelis
2,
Gianluigi Giannelli
1 and
Francesco Russo
1,*,†
1
National Institute of Gastroenterology IRCCS “S. de Bellis” Research Hospital, 70013 Castellana Grotte, Italy
2
Department of Soil, Plant and Food Science, University of Bari Aldo Moro, 70126 Bari, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2022, 14(21), 4628; https://doi.org/10.3390/nu14214628
Submission received: 3 October 2022 / Revised: 31 October 2022 / Accepted: 1 November 2022 / Published: 2 November 2022
(This article belongs to the Section Nutrition and Metabolism)
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Abstract

Since irritable bowel syndrome (IBS)—a common gastrointestinal (GI) disorder—still lacks effective therapy, a nutritional approach may represent a practical alternative. Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications. More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD). We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks. Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups. After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one. Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid). Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.
Keywords: diet; functional gastrointestinal disorders; irritable bowel syndrome; metabolome; short-chain fatty acids; Tritordeum; volatile organic compounds diet; functional gastrointestinal disorders; irritable bowel syndrome; metabolome; short-chain fatty acids; Tritordeum; volatile organic compounds
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MDPI and ACS Style

Caponio, G.R.; Celano, G.; Calabrese, F.M.; Riezzo, G.; Orlando, A.; D’Attoma, B.; Ignazzi, A.; Vacca, M.; Porrelli, A.; Tutino, V.; et al. Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation. Nutrients 2022, 14, 4628. https://doi.org/10.3390/nu14214628

AMA Style

Caponio GR, Celano G, Calabrese FM, Riezzo G, Orlando A, D’Attoma B, Ignazzi A, Vacca M, Porrelli A, Tutino V, et al. Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation. Nutrients. 2022; 14(21):4628. https://doi.org/10.3390/nu14214628

Chicago/Turabian Style

Caponio, Giusy Rita, Giuseppe Celano, Francesco Maria Calabrese, Giuseppe Riezzo, Antonella Orlando, Benedetta D’Attoma, Antonia Ignazzi, Mirco Vacca, Annalisa Porrelli, Valeria Tutino, and et al. 2022. "Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation" Nutrients 14, no. 21: 4628. https://doi.org/10.3390/nu14214628

APA Style

Caponio, G. R., Celano, G., Calabrese, F. M., Riezzo, G., Orlando, A., D’Attoma, B., Ignazzi, A., Vacca, M., Porrelli, A., Tutino, V., De Angelis, M., Giannelli, G., & Russo, F. (2022). Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation. Nutrients, 14(21), 4628. https://doi.org/10.3390/nu14214628

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