Effects of Lactiplantibacillus plantarum OLL2712 on Memory Function in Older Adults with Declining Memory: A Randomized Placebo-Controlled Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Test Foods
2.3. Memory Functions Tests
2.4. Assessment of Daily Nutritional Intake
2.5. Gut Microbiota Analysis
2.6. Statistical Analysis
3. Results
3.1. Participant Characteristics
3.2. Analysis of the Effects of OLL2712 on Memory Function without the Influence of Daily Nutritional Intake and Participant Characteristics
3.3. Analysis of the Effects of OLL2712 on Memory Function with the Influence of Daily Nutritional Intake and Participant Characteristics
3.4. Gut Microbiota Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Item | Active (n = 39) | Placebo (n = 39) | p-Value |
---|---|---|---|
Age | 76.8 ± 4.6 a | 76.9 ± 4.9 a | 0.906 c |
Sex (Male/Female) | 18/21 b | 18/21 b | 1.000 d |
Years of Education | 13.9 ± 2.4 a | 14.0 ± 2.1 a | 0.804 c |
BMI | 21.7 ± 2.5 a | 22.3 ± 3.4 a | 0.352 c |
Domain | Start-Up | Follow-Up | Δ | ||||
---|---|---|---|---|---|---|---|
Active | Placebo | Active | Placebo | Active | Placebo | p-Value | |
Visual memory | 41.7 ± 5.9 | 43.3 ± 4.1 | 42.7 ± 5.0 | 41.6 ± 4.6 | 1.1 ± 6.1 | −1.6 ± 5.5 | 0.044 * |
Verbal memory | 49.6 ± 6.2 | 49.5 ± 5.1 | 49.4 ± 6.1 | 48.1 ± 5.7 | −0.2 ± 5.2 | −1.4 ± 6.3 | 0.359 |
Composite memory | 91.3 ± 9.7 | 92.8 ± 8.0 | 92.2 ± 9.3 | 89.7 ± 8.1 | 0.8 ± 8.3 | −3.1 ± 9.6 | 0.058 |
Variable | β | SE β | p | VIF |
---|---|---|---|---|
Group | 0.267 | 0.113 | 0.021 * | 1.042 |
Cholesterol | −0.187 | 0.113 | 0.101 | 1.042 |
P | 0.034 * | |||
R2adj | 0.062 |
Variable | β | SE β | p | VIF |
---|---|---|---|---|
Group | 0.224 | 0.109 | 0.044 * | 1.048 |
Cholesterol | −0.387 | 0.137 | 0.006 ** | 1.653 |
Fat-soluble vitamins | 0.385 | 0.137 | 0.006 ** | 1.639 |
P | 0.005 ** | |||
R2adj | 0.125 |
Variable | β | SE β | p | VIF |
---|---|---|---|---|
Group | 0.263 | 0.112 | 0.021 * | 1.053 |
Sex | 0.223 | 0.126 | 0.081 | 1.339 |
Years of education | 0.164 | 0.124 | 0.189 | 1.295 |
Cholesterol | −0.308 | 0.127 | 0.018 * | 1.357 |
Vitamin K | 0.241 | 0.117 | 0.043 * | 1.158 |
P | 0.039 * | |||
R2adj | 0.088 |
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Sakurai, K.; Toshimitsu, T.; Okada, E.; Anzai, S.; Shiraishi, I.; Inamura, N.; Kobayashi, S.; Sashihara, T.; Hisatsune, T. Effects of Lactiplantibacillus plantarum OLL2712 on Memory Function in Older Adults with Declining Memory: A Randomized Placebo-Controlled Trial. Nutrients 2022, 14, 4300. https://doi.org/10.3390/nu14204300
Sakurai K, Toshimitsu T, Okada E, Anzai S, Shiraishi I, Inamura N, Kobayashi S, Sashihara T, Hisatsune T. Effects of Lactiplantibacillus plantarum OLL2712 on Memory Function in Older Adults with Declining Memory: A Randomized Placebo-Controlled Trial. Nutrients. 2022; 14(20):4300. https://doi.org/10.3390/nu14204300
Chicago/Turabian StyleSakurai, Keisuke, Takayuki Toshimitsu, Erika Okada, Saya Anzai, Izumi Shiraishi, Noriko Inamura, Satoru Kobayashi, Toshihiro Sashihara, and Tatsuhiro Hisatsune. 2022. "Effects of Lactiplantibacillus plantarum OLL2712 on Memory Function in Older Adults with Declining Memory: A Randomized Placebo-Controlled Trial" Nutrients 14, no. 20: 4300. https://doi.org/10.3390/nu14204300