Next Article in Journal
Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 Infection
Next Article in Special Issue
Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin Resistance, and New Onset Diabetes after Peritoneal Dialysis
Previous Article in Journal
Targeting Alzheimer’s Disease: The Critical Crosstalk between the Liver and Brain
Previous Article in Special Issue
Novel Insights in the Physiopathology and Management of Obesity-Related Kidney Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 14
Issue 20
10.3390/nu14204297
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease

by
Fredzzia Graterol Torres
1,2,*,†,
María Molina
1,2,†,
Jordi Soler-Majoral
1,
Gregorio Romero-González
1,3,
Néstor Rodríguez Chitiva
1,
Maribel Troya-Saborido
1,2,
Guillem Socias Rullan
4,
Elena Burgos
1,
Javier Paúl Martínez
1,
Marina Urrutia Jou
1,
Carles Cañameras
1,
Josep Riera Sadurní
1,
Anna Vila
1 and
Jordi Bover
1
1
Nephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain
2
Medicine Department, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain
3
International Renal Research Institute of Vicenza, 36100 Vicenza, Italy
4
Endocrinology and Nutrition Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2022, 14(20), 4297; https://doi.org/10.3390/nu14204297
Submission received: 26 July 2022 / Revised: 30 September 2022 / Accepted: 7 October 2022 / Published: 14 October 2022
(This article belongs to the Special Issue Relevant Nutritional, Biochemical and Molecular Disorders in CKD)
Browse Figure
Review Reports Versions Notes

Abstract

While patient care, kidney replacement therapy, and transplantation techniques for chronic kidney disease (CKD) have continued to progress, the incidence of malnutrition disorders in CKD appears to have remained unchanged over time. However, there is now a better understanding of the underlying pathophysiology according to the disease background, disease stage, and the treatment received. In CKD patients, the increased production of proinflammatory cytokines and oxidative stress lead to a proinflammatory milieu that is at least partially responsible for the increased morbidity and mortality in this patient population. New insights into the pathogenic role of innate immunity and the proinflammatory cytokine profile, characterized, for instance, by higher levels of IL-6 and TNF-α, explain some of the clinical and laboratory abnormalities observed in these patients. In this article, we will explore currently available nutritional–inflammatory biomarkers in distinct CKD populations (hemodialysis, peritoneal dialysis, transplantation) with a view to evaluating their efficacy as predictors of malnutrition and their involvement in the common proinflammatory process. Although there is a direct relationship between inflammatory-nutritional status, signs and symptoms [e.g., protein-energy wasting (PEW), anorexia], and comorbidities (e.g., atheromatosis, atherosclerosis), we are in need of clearly standardized markers for nutritional-inflammatory assessment to improve their performance and design appropriate bidirectional interventions.
Keywords: chronic kidney disease; CKD; malnutrition; sarcopenia; cytokines; inflammation; proinflammatory cytokines; protein-energy wasting; malnutrition; malnutrition inflammation cachexia syndrome; MICS; malnutrition-inflammation score; MIS chronic kidney disease; CKD; malnutrition; sarcopenia; cytokines; inflammation; proinflammatory cytokines; protein-energy wasting; malnutrition; malnutrition inflammation cachexia syndrome; MICS; malnutrition-inflammation score; MIS

Share and Cite

MDPI and ACS Style

Graterol Torres, F.; Molina, M.; Soler-Majoral, J.; Romero-González, G.; Rodríguez Chitiva, N.; Troya-Saborido, M.; Socias Rullan, G.; Burgos, E.; Paúl Martínez, J.; Urrutia Jou, M.; et al. Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease. Nutrients 2022, 14, 4297. https://doi.org/10.3390/nu14204297

AMA Style

Graterol Torres F, Molina M, Soler-Majoral J, Romero-González G, Rodríguez Chitiva N, Troya-Saborido M, Socias Rullan G, Burgos E, Paúl Martínez J, Urrutia Jou M, et al. Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease. Nutrients. 2022; 14(20):4297. https://doi.org/10.3390/nu14204297

Chicago/Turabian Style

Graterol Torres, Fredzzia, María Molina, Jordi Soler-Majoral, Gregorio Romero-González, Néstor Rodríguez Chitiva, Maribel Troya-Saborido, Guillem Socias Rullan, Elena Burgos, Javier Paúl Martínez, Marina Urrutia Jou, and et al. 2022. "Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease" Nutrients 14, no. 20: 4297. https://doi.org/10.3390/nu14204297

APA Style

Graterol Torres, F., Molina, M., Soler-Majoral, J., Romero-González, G., Rodríguez Chitiva, N., Troya-Saborido, M., Socias Rullan, G., Burgos, E., Paúl Martínez, J., Urrutia Jou, M., Cañameras, C., Riera Sadurní, J., Vila, A., & Bover, J. (2022). Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease. Nutrients, 14(20), 4297. https://doi.org/10.3390/nu14204297

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop