Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Population
2.2. Biochemical Analyses
2.3. DNA Extraction
2.4. LTL Determination
2.5. Statistical Methods
3. Results
3.1. Baseline Characteristics
3.2. Effects of Intervention on Leukocyte Telomere Length
3.3. Difference in Change of LTL as Related to CV Mortality
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Active Treatment Group n = 67 | Placebo Group n = 51 | |
---|---|---|
Age, median (range) | 77 (14) | 77 (15) |
Females 65/Males 53 | 35/32 | 30/21 |
History | ||
Smoking, n (%) | 7 (10) | 6 (12) |
Diabetes, n (%) | 10 (15) | 9 (18) |
Hypertension, n (%) | 46 (69) | 40 (78) |
Hb, mean (SD), g/L | 137 (19.5) | 136 (12.6) |
IHD, n (%) | 17 (25) | 8 (16) |
NYHA class I, n (%) | 36 (54) | 32 (63) |
NYHA class II, n (%) | 17 (25) | 14 (28) |
NYHA class III, n (%) | 14 (21) | 4 (8) |
NYHA class IV, n | 0 | 0 |
Unclassified, n | 0 | 1 |
Medications | ||
Anticoagulants, n (%) | 5 (8) | 5 (10) |
ACEI/ARB, n (%) | 8 (12) | 10 (20) |
Beta-blockers, n (%) | 25 (37) | 19 (37) |
Diuretics, n (%) | 22 (33) | 17 (33) |
Statins, n (%) | 14 (21) | 11 (22) |
Se conc. incl. mean (SD), µg/L | 66.5 (15.9) | 67.4 (17.2) |
Se conc. 48 months, mean (SD) µg/L | 208.7 (57.0) | 71.6 (24.9) |
Q10 conc. incl. mean (SD mg/L | 0.82 (0.31) | 0.81 (0.31) |
Q10 conc. 48 months, mean (SD) mg/L | 2.19 (1.35) | 0.90 (0.36) |
Examinations | ||
EF < 40%, n (%) | 5 (7) | 2 (4) |
Atrial fibrillation, n (%) | 3 (5) | 3 (6) |
Mortality | ||
CV death, n (%) | 12 (18) | 12 (24) |
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Opstad, T.B.; Alexander, J.; Aaseth, J.O.; Larsson, A.; Seljeflot, I.; Alehagen, U. Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial. Nutrients 2022, 14, 3346. https://doi.org/10.3390/nu14163346
Opstad TB, Alexander J, Aaseth JO, Larsson A, Seljeflot I, Alehagen U. Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial. Nutrients. 2022; 14(16):3346. https://doi.org/10.3390/nu14163346
Chicago/Turabian StyleOpstad, Trine Baur, Jan Alexander, Jan O. Aaseth, Anders Larsson, Ingebjørg Seljeflot, and Urban Alehagen. 2022. "Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial" Nutrients 14, no. 16: 3346. https://doi.org/10.3390/nu14163346