Next Article in Journal
Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies
Previous Article in Journal
Interactions between Vitamin D Genetic Risk and Dietary Factors on Metabolic Disease-Related Outcomes in Ghanaian Adults
 
 
Review

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

1
Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh 47000, Selangor, Malaysia
2
Department of Paediatrics, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh 47000, Selangor, Malaysia
3
Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh 47000, Selangor, Malaysia
4
Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh 47000, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Susanne Klaus
Nutrients 2022, 14(13), 2766; https://doi.org/10.3390/nu14132766
Received: 9 June 2022 / Revised: 29 June 2022 / Accepted: 29 June 2022 / Published: 5 July 2022
(This article belongs to the Special Issue Adiposity, Diabetes and Metabolic Diseases)
Metabolic syndrome (MS) is a multifactorial disease entity and is not fully understood. Growing evidence suggests that early exposure to bisphenol A (BPA) is a significant risk factor for the development of metabolic diseases. BPA is a monomer used in the manufacturing of polycarbonate plastics, thermal receipt paper, and epoxy resins. Owing to its widespread use, BPA has been detected in human fluids and tissues, including blood, placental breast milk, and follicular fluid. In the present review, we aimed to review the impact of prenatal exposure to different doses of BPA on metabolic parameters as determined by in vivo and epidemiological studies. The PubMed, Scopus, and Web of Science electronic databases were searched to identify articles published during a period of 15 years from 2006 to 2021, and 29 studies met the criteria. Most studies demonstrated that prenatal exposure to low BPA concentrations correlated with alterations in metabolic parameters in childhood and an increased risk of metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM), in adulthood. Therefore, prenatal exposure to low doses of BPA may be associated with an increased risk of obesity and T2DM in a sex-specific manner. View Full-Text
Keywords: bisphenol A; endocrine disruption; metabolic disorder; diabetes mellitus; obesity; insulin resistance bisphenol A; endocrine disruption; metabolic disorder; diabetes mellitus; obesity; insulin resistance
Show Figures

Figure 1

MDPI and ACS Style

Abulehia, H.F.S.; Mohd Nor, N.S.; Sheikh Abdul Kadir, S.H. The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence. Nutrients 2022, 14, 2766. https://doi.org/10.3390/nu14132766

AMA Style

Abulehia HFS, Mohd Nor NS, Sheikh Abdul Kadir SH. The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence. Nutrients. 2022; 14(13):2766. https://doi.org/10.3390/nu14132766

Chicago/Turabian Style

Abulehia, Hala F. S., Noor Shafina Mohd Nor, and Siti Hamimah Sheikh Abdul Kadir. 2022. "The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence" Nutrients 14, no. 13: 2766. https://doi.org/10.3390/nu14132766

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop