Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study

Clinical Study Department, Complife (Beijing) Testing Technology Co., Ltd., Beizhan North Street N.17, Room 902—Xicheng District, Beijing 100089, China

Active S.r.l., R&D Department, Piano Tavola, 95032 Belpasso, CT, Italy

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Alma Mater Europea, 6000 Koper, Slovenia

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Bionap S.r.l. R&D Department, Piano Tavola, 95032 Belpasso, CT, Italy

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Department of Drug and Health Science, University of Catania, Viale A. Doria, 95125 Catania, CT, Italy

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CERNUT, Research Centre on Nutraceuticals and Health Products, University of Catania, Viale A. Doria, 95125 Catania, CT, Italy

Authors to whom correspondence should be addressed.

Academic Editor: Rosane Marina Peralta

Nutrients 2022, 14(11), 2241; https://doi.org/10.3390/nu14112241

Received: 28 April 2022 / Revised: 18 May 2022 / Accepted: 24 May 2022 / Published: 27 May 2022

(This article belongs to the Section Phytochemicals and Human Health)

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Abstract

The increase in solar ultraviolet radiation (UVR) that reaches the Earth’s surface should make us reflect on the need to develop new approaches in protecting the skin from UVR exposure. The present study aims to evaluate the photoprotective and antiaging efficacy of a red orange extract (100 mg/day) in both Asian and Caucasian subjects. A randomized, double-blind, controlled study was carried out in 110 Asian and Caucasian subjects. Product efficacy was measured as follows: (1) the photoprotective effect was measured by the minimal erythema dose (MED) assessment; (2) the efficacy in decreasing the UVA+B-induced skin redness was measured by colorimetry; (3) the antioxidant efficacy was measured by the ferric-reducing antioxidant power (FRAP) and the malondialdehyde (MDA) assay; and (4) skin moisturization, skin elasticity, skin radiance, the intensity of melanin staining, transepidermal water loss (TEWL), and wrinkles were measured to assess the antiaging efficacy. The intake of the product for 56 days was effective in improving the skin reaction to UV exposure; in increasing the skin antioxidant capacity as well as in decreasing UVA-induced lipid peroxidation; in increasing the skin moisturization, skin elasticity, and skin radiance; and in decreasing TEWL, the intensity of melanin staining inside dark spots, and wrinkle depth. Our results suggest that the test product is effective in counteracting both the harmful effects of UVR exposure and aging signs. View Full-Text

Keywords: oral photoprotection; skin aging; oxidative stress; clinical study; red orange extract; food supplement; skin moisturization; skin elasticity

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MDPI and ACS Style

Nobile, V.; Burioli, A.; Yu, S.; Zhifeng, S.; Cestone, E.; Insolia, V.; Zaccaria, V.; Malfa, G.A. Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study. Nutrients 2022, 14, 2241. https://doi.org/10.3390/nu14112241

AMA Style

Nobile V, Burioli A, Yu S, Zhifeng S, Cestone E, Insolia V, Zaccaria V, Malfa GA. Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study. Nutrients. 2022; 14(11):2241. https://doi.org/10.3390/nu14112241

Chicago/Turabian Style

Nobile, Vincenzo, Andrea Burioli, Sara Yu, Shi Zhifeng, Enza Cestone, Violetta Insolia, Vincenzo Zaccaria, and Giuseppe A. Malfa. 2022. "Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study" Nutrients 14, no. 11: 2241. https://doi.org/10.3390/nu14112241

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Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study

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