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Article

Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence?

by
Thomas Sauvaitre
1,2,
Florence Van Herreweghen
2,
Karen Delbaere
2,
Claude Durif
1,
Josefien Van Landuyt
2,
Khaled Fadhlaoui
1,
Ségolène Huille
3,
Frédérique Chaucheyras-Durand
1,4,
Lucie Etienne-Mesmin
1,
Stéphanie Blanquet-Diot
1,*,† and
Tom Van de Wiele
2,†
1
UMR 454 INRAE, Microbiology, Digestive Environment and Health (MEDIS), Université Clermont Auvergne, 28 Place Henri Dunant, F-63000 Clermont-Ferrand, France
2
Center for Microbial Ecology and Technology (CMET), Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium
3
HARi&CO, 10 Rue Pierre Semard, F-69007 Lyon, France
4
Lallemand SAS, 19 Rue des Briquetiers, BP 59, CEDEX, F-31702 Blagnac, France
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2022, 14(10), 2146; https://doi.org/10.3390/nu14102146
Submission received: 12 April 2022 / Revised: 16 May 2022 / Accepted: 18 May 2022 / Published: 21 May 2022
(This article belongs to the Special Issue Prebiotics and Probiotics in Immune Health)
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Abstract

Dietary fibers exhibit well-known beneficial effects on human health, but their anti-infectious properties against enteric pathogens have been poorly investigated. Enterotoxigenic Escherichia coli (ETEC) is a major food-borne pathogen that causes acute traveler’s diarrhea. Its virulence traits mainly rely on adhesion to an epithelial surface, mucus degradation, and the secretion of two enterotoxins associated with intestinal inflammation. With the increasing burden of antibiotic resistance worldwide, there is an imperious need to develop novel alternative strategies to control ETEC infections. This study aimed to investigate, using complementary in vitro approaches, the inhibitory potential of two dietary-fiber-containing products (a lentil extract and yeast cell walls) against the human ETEC reference strain H10407. We showed that the lentil extract decreased toxin production in a dose-dependent manner, reduced pro-inflammatory interleukin-8 production, and modulated mucus-related gene induction in ETEC-infected mucus-secreting intestinal cells. We also report that the yeast product reduced ETEC adhesion to mucin and Caco-2/HT29-MTX cells. Both fiber-containing products strengthened intestinal barrier function and modulated toxin-related gene expression. In a complex human gut microbial background, both products did not elicit a significant effect on ETEC colonization. These pioneering data demonstrate the promising role of dietary fibers in controlling different stages of the ETEC infection process.
Keywords: dietary fiber; enterotoxigenic Escherichia coli; virulence; mucus; fecal microbiota; innate immune response dietary fiber; enterotoxigenic Escherichia coli; virulence; mucus; fecal microbiota; innate immune response

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MDPI and ACS Style

Sauvaitre, T.; Van Herreweghen, F.; Delbaere, K.; Durif, C.; Van Landuyt, J.; Fadhlaoui, K.; Huille, S.; Chaucheyras-Durand, F.; Etienne-Mesmin, L.; Blanquet-Diot, S.; et al. Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence? Nutrients 2022, 14, 2146. https://doi.org/10.3390/nu14102146

AMA Style

Sauvaitre T, Van Herreweghen F, Delbaere K, Durif C, Van Landuyt J, Fadhlaoui K, Huille S, Chaucheyras-Durand F, Etienne-Mesmin L, Blanquet-Diot S, et al. Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence? Nutrients. 2022; 14(10):2146. https://doi.org/10.3390/nu14102146

Chicago/Turabian Style

Sauvaitre, Thomas, Florence Van Herreweghen, Karen Delbaere, Claude Durif, Josefien Van Landuyt, Khaled Fadhlaoui, Ségolène Huille, Frédérique Chaucheyras-Durand, Lucie Etienne-Mesmin, Stéphanie Blanquet-Diot, and et al. 2022. "Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence?" Nutrients 14, no. 10: 2146. https://doi.org/10.3390/nu14102146

APA Style

Sauvaitre, T., Van Herreweghen, F., Delbaere, K., Durif, C., Van Landuyt, J., Fadhlaoui, K., Huille, S., Chaucheyras-Durand, F., Etienne-Mesmin, L., Blanquet-Diot, S., & Van de Wiele, T. (2022). Lentils and Yeast Fibers: A New Strategy to Mitigate Enterotoxigenic Escherichia coli (ETEC) Strain H10407 Virulence? Nutrients, 14(10), 2146. https://doi.org/10.3390/nu14102146

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