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Article

Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly Subjects to COVID-19 Vaccination: A Randomized Controlled Trial

1
Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, Spain
2
Pharmacology Group, Health Research Institute Santiago Compostela (IDIS), 15706 Santiago de Compostela, Spain
3
Medicina Familiar y Comunitaria, 15706 Santiago de Compostela, Spain
4
Research and Development Department, Biosearch Life, a Kerry Company, 18004 Granada, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Alba Rodriguez-Nogales
Nutrients 2022, 14(1), 228; https://doi.org/10.3390/nu14010228
Received: 14 December 2021 / Revised: 29 December 2021 / Accepted: 2 January 2022 / Published: 5 January 2022
(This article belongs to the Special Issue Role of Lactobacillus and Probiotics in Human Health and Diseases)
Elderly people are particularly vulnerable to COVID-19, with a high risk of developing severe disease and a reduced immune response to the COVID-19 vaccine. A randomized, placebo-controlled, double-blind trial to assess the effect of the consumption of the probiotic Loigolactobacillus coryniformis K8 CECT 5711 on the immune response generated by the COVID-19 vaccine in an elderly population was performed. Two hundred nursing home residents >60 yrs that had not COVID-19 were randomized to receive L. coryniformis K8 or a placebo daily for 3 months. All volunteers received a complete vaccination schedule of a mRNA vaccine, starting the intervention ten days after the first dose. Specific IgG and IgA antibody levels were analyzed 56 days after the end of the immunization process. No differences between the groups were observed in the antibody levels. During the intervention, 19 subjects had COVID-19 (11 receiving K8 vs. 8 receiving placebo, p = 0.457). Subgroup analysis in these patients showed that levels of IgG were significantly higher in those receiving K8 compared to placebo (p = 0.038). Among subjects >85 yrs that did not get COVID-19, administration of K8 tended to increase the IgA levels (p = 0.082). The administration of K8 may enhance the specific immune response against COVID-19 and may improve the COVID-19 vaccine-specific responses in elderly populations. View Full-Text
Keywords: COVID-19; probiotic; immune response; elderly COVID-19; probiotic; immune response; elderly
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MDPI and ACS Style

Fernández-Ferreiro, A.; Formigo-Couceiro, F.J.; Veiga-Gutierrez, R.; Maldonado-Lobón, J.A.; Hermida-Cao, A.M.; Rodriguez, C.; Bañuelos, O.; Olivares, M.; Blanco-Rojo, R. Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly Subjects to COVID-19 Vaccination: A Randomized Controlled Trial. Nutrients 2022, 14, 228. https://doi.org/10.3390/nu14010228

AMA Style

Fernández-Ferreiro A, Formigo-Couceiro FJ, Veiga-Gutierrez R, Maldonado-Lobón JA, Hermida-Cao AM, Rodriguez C, Bañuelos O, Olivares M, Blanco-Rojo R. Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly Subjects to COVID-19 Vaccination: A Randomized Controlled Trial. Nutrients. 2022; 14(1):228. https://doi.org/10.3390/nu14010228

Chicago/Turabian Style

Fernández-Ferreiro, Anxo, Francisco J. Formigo-Couceiro, Roi Veiga-Gutierrez, Jose A. Maldonado-Lobón, Ana M. Hermida-Cao, Carlos Rodriguez, Oscar Bañuelos, Mónica Olivares, and Ruth Blanco-Rojo. 2022. "Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly Subjects to COVID-19 Vaccination: A Randomized Controlled Trial" Nutrients 14, no. 1: 228. https://doi.org/10.3390/nu14010228

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