Next Article in Journal
The Effect of Dietary Interventions on Chronic Inflammatory Diseases in Relation to the Microbiome: A Systematic Review
Previous Article in Journal
Food Intolerance: The Role of Histamine
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 13
Issue 9
10.3390/nu13093206
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study

by
Bumhee Yang
1,†,
Kyungdo Han
2,†,
Sang Hyuk Kim
3,
Dong-Hwa Lee
4,
Sang Hyun Park
2,
Jung Eun Yoo
5,
Dong Wook Shin
6,7,
Hayoung Choi
8,* and
Hyun Lee
9,*
1
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju 28644, Korea
2
Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea
3
Samsung Medical Center, Department of Medicine, Division of Pulmonology and Critical Care Medicine, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
4
Department of Internal Medicine, Division of Endocrinology and Metabolism, Chungbuk National University Hospital, Cheongju 28644, Korea
5
Healthcare System Gangnam Center, Department of Family Medicine, Seoul National University Hospital, Seoul 03080, Korea
6
Samsung Medical Center, Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
7
Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea
8
Department of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Korea
9
Department of Internal Medicine, Division of Pulmonary Medicine and Allergy, Hanyang University College of Medicine, Seoul 04763, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2021, 13(9), 3206; https://doi.org/10.3390/nu13093206
Submission received: 17 August 2021 / Revised: 8 September 2021 / Accepted: 9 September 2021 / Published: 15 September 2021
(This article belongs to the Section Nutrition and Public Health)
Browse Figures
Review Reports Versions Notes

Abstract

Although body mass index (BMI) is a potential risk factor for bronchiectasis in young adults, the association between BMI and incident bronchiectasis has not been well elucidated. This study included 6,329,838 individuals aged 20–40 years from the Korean National Health Insurance Service database 2009–2012 who were followed up until the date of the diagnosis of bronchiectasis, death, or 31 December 2018. We evaluated the incidence and risk of bronchiectasis according to the BMI category. The incidence rate of bronchiectasis increased as BMI decreased in a dose-dependent manner (p for trend <0.01). In multivariable Cox regression analysis, being underweight was an independent risk factor for the development of bronchiectasis, with a hazard ratio of 1.24 (95% confidence interval, 1.19–1.30) compared to being normal weight. In subgroup analysis, the effect of being underweight on the development of bronchiectasis was more evident in males and older individuals (30–40 years) than females and younger individuals (20–29 years), respectively (p for interaction <0.01 for both). These results remained significant in subgroup analysis in which subjects with comorbidities related to being underweight were excluded. Being underweight may be a novel risk factor for the development of bronchiectasis in young adults.
Keywords: bronchiectasis; body mass index; underweight; risk factors; young adults bronchiectasis; body mass index; underweight; risk factors; young adults
Graphical Abstract

Share and Cite

MDPI and ACS Style

Yang, B.; Han, K.; Kim, S.H.; Lee, D.-H.; Park, S.H.; Yoo, J.E.; Shin, D.W.; Choi, H.; Lee, H. Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study. Nutrients 2021, 13, 3206. https://doi.org/10.3390/nu13093206

AMA Style

Yang B, Han K, Kim SH, Lee D-H, Park SH, Yoo JE, Shin DW, Choi H, Lee H. Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study. Nutrients. 2021; 13(9):3206. https://doi.org/10.3390/nu13093206

Chicago/Turabian Style

Yang, Bumhee, Kyungdo Han, Sang Hyuk Kim, Dong-Hwa Lee, Sang Hyun Park, Jung Eun Yoo, Dong Wook Shin, Hayoung Choi, and Hyun Lee. 2021. "Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study" Nutrients 13, no. 9: 3206. https://doi.org/10.3390/nu13093206

APA Style

Yang, B., Han, K., Kim, S. H., Lee, D.-H., Park, S. H., Yoo, J. E., Shin, D. W., Choi, H., & Lee, H. (2021). Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study. Nutrients, 13(9), 3206. https://doi.org/10.3390/nu13093206

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop