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Article

Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness

1
Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan
2
Department of Intensive Care Center, Kitasato University Hospital, Sagamihara 252-0329, Japan
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Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Japan
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Department of Rehabilitation, Kitasato University Hospital, Sagamihara 252-0329, Japan
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Department of Anesthesiology, School of Medicine, Kitasato University, Sagamihara 252-0373, Japan
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Division of Intensive Care Medicine, Department of Research and Development Center for New Medical Frontiers, School of Medicine, Kitasato University, Sagamihara 252-0373, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: David C. Nieman
Nutrients 2021, 13(8), 2726; https://doi.org/10.3390/nu13082726
Received: 28 June 2021 / Revised: 2 August 2021 / Accepted: 5 August 2021 / Published: 8 August 2021
Skeletal muscle wasting in the intensive care unit (ICU) has been associated with mortality, but it is unclear whether sarcopenia, defined by skeletal muscle mass and function, is useful for detailed risk stratification after ICU discharge. In this cohort study, 72 critically ill patients with an ICU stay of ≥48 h were identified. Skeletal muscle mass was assessed from the muscle thickness (MT) of the patients’ quadriceps using ultrasound images before ICU discharge. Skeletal muscle function was assessed from the patients’ muscle strength (MS) before ICU discharge according to the Medical Research Council sum score. A diagnosis of sarcopenia in the ICU was made in patients with low MT and low MS. The study endpoint was 1-year mortality. Sarcopenia in the ICU was diagnosed in 26/72 patients (36%). After adjusting for covariates in the Cox regression, sarcopenia in the ICU was significantly associated with 1-year mortality (hazard ratio 3.82; 95% confidence interval, 1.40–10.42). Sarcopenia in the ICU, defined by low skeletal muscle mass and function, was associated with 1-year mortality in survivors of critical illness. Skeletal muscle mass and function assessed at the bedside could be used to identify higher-risk patients in the ICU. View Full-Text
Keywords: critical illness; sarcopenia; skeletal muscle mass; skeletal muscle function; ultrasound critical illness; sarcopenia; skeletal muscle mass; skeletal muscle function; ultrasound
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MDPI and ACS Style

Yanagi, N.; Koike, T.; Kamiya, K.; Hamazaki, N.; Nozaki, K.; Ichikawa, T.; Matsunaga, A.; Kuroiwa, M.; Arai, M. Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness. Nutrients 2021, 13, 2726. https://doi.org/10.3390/nu13082726

AMA Style

Yanagi N, Koike T, Kamiya K, Hamazaki N, Nozaki K, Ichikawa T, Matsunaga A, Kuroiwa M, Arai M. Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness. Nutrients. 2021; 13(8):2726. https://doi.org/10.3390/nu13082726

Chicago/Turabian Style

Yanagi, Naoya, Tomotaka Koike, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Atsuhiko Matsunaga, Masayuki Kuroiwa, and Masayasu Arai. 2021. "Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness" Nutrients 13, no. 8: 2726. https://doi.org/10.3390/nu13082726

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