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The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

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Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain
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Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
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Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain
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Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III, 28029 Madrid, Spain
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National Centre for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
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Department of Epidemiology, Centre of Public Health, Medical University of Vienna, 1090 Vienna, Austria
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Facultad de Medicina, Universidad de Cantabria—IDIVAL, 39011 Santander, Spain
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Cáncer y Salud Pública, FISABIO, 46020 Valencia, Spain
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Department of Preventive Medicine and Public Health, Universidad de Granada, 18016 Granada, Spain
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Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain
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Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Campus Universitario de El Carmen, 21071 Huelva, Spain
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Instituto de Investigación Sanitaria del Principado de Asturias (ISPA) and IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain
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Cancer Epidemiology Research Programme IDIBELL, Institut Català d’Oncologia, 08908 L’Hospitalet de Llobregat, Spain
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Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Lynnette Ferguson
Nutrients 2021, 13(8), 2662; https://doi.org/10.3390/nu13082662
Received: 21 June 2021 / Revised: 22 July 2021 / Accepted: 27 July 2021 / Published: 30 July 2021
(This article belongs to the Section Nutrition and Public Health)
Nighttime fasting has been inconclusively associated with a reduced risk of cancer. The purpose of this study was to investigate this association in relation to prostate cancer risk. We examined data from 607 prostate cancer cases and 848 population controls who had never worked in night shift work from the Spanish multicase-control (MCC) study, 2008–2013. Through an interview, we collected circadian information on meal timing at mid-age. We estimated odds ratios (OR) and 95% confidence intervals (CI) with unconditional logistic regression. After controlling for time of breakfast, fasting for more than 11 h overnight (the median duration among controls) was associated with a reduced risk of prostate cancer compared to those fasting for 11 h or less (OR = 0.77, 95% 0.54–1.07). Combining a long nighttime fasting and an early breakfast was associated with a lower risk of prostate cancer compared to a short nighttime fasting and a late breakfast (OR = 0.54, 95% CI 0.27–1.04). This study suggests that a prolonged nighttime fasting duration and an early breakfast may be associated with a lower risk of prostate cancer. Findings should be interpreted cautiously and add to growing evidence on the importance of chrononutrition in relation to cancer risk. View Full-Text
Keywords: prostate cancer; prolonged nighttime fasting; early time-restricted feeding; circadian rhythms; breakfast; chrononutrition prostate cancer; prolonged nighttime fasting; early time-restricted feeding; circadian rhythms; breakfast; chrononutrition
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MDPI and ACS Style

Palomar-Cros, A.; Espinosa, A.; Straif, K.; Pérez-Gómez, B.; Papantoniou, K.; Gómez-Acebo, I.; Molina-Barceló, A.; Olmedo-Requena, R.; Alguacil, J.; Fernández-Tardón, G.; Casabonne, D.; Aragonés, N.; Castaño-Vinyals, G.; Pollán, M.; Romaguera, D.; Kogevinas, M. The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain. Nutrients 2021, 13, 2662. https://doi.org/10.3390/nu13082662

AMA Style

Palomar-Cros A, Espinosa A, Straif K, Pérez-Gómez B, Papantoniou K, Gómez-Acebo I, Molina-Barceló A, Olmedo-Requena R, Alguacil J, Fernández-Tardón G, Casabonne D, Aragonés N, Castaño-Vinyals G, Pollán M, Romaguera D, Kogevinas M. The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain. Nutrients. 2021; 13(8):2662. https://doi.org/10.3390/nu13082662

Chicago/Turabian Style

Palomar-Cros, Anna, Ana Espinosa, Kurt Straif, Beatriz Pérez-Gómez, Kyriaki Papantoniou, Inés Gómez-Acebo, Ana Molina-Barceló, Rocío Olmedo-Requena, Juan Alguacil, Guillermo Fernández-Tardón, Delphine Casabonne, Nuria Aragonés, Gemma Castaño-Vinyals, Marina Pollán, Dora Romaguera, and Manolis Kogevinas. 2021. "The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain" Nutrients 13, no. 8: 2662. https://doi.org/10.3390/nu13082662

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