Next Article in Journal
What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review
Previous Article in Journal
Anti-Salmonella Activity and Peptidomic Profiling of Peptide Fractions Produced from Sturgeon Fish Skin Collagen (Huso huso) Using Commercial Enzymes
Previous Article in Special Issue
Modulation of the Gut Microbiota Structure with Probiotics and Isoflavone Alleviates Metabolic Disorder in Ovariectomized Mice
 
 
Article

Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial

1
Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi 11759, Korea
2
Department of Neuropsychiatry, School of Medicine, Eulji University, Daejeon 34824, Korea
3
Department of Psychiatry, Bundang Hospital, Seoul National University, Seongnam 13620, Korea
4
Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
5
PB Department, Navipharm Inc., Suwon 16209, Korea
6
Department of Psychiatry, School of Medicine, Seoul National University, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Henning Sommermeyer
Nutrients 2021, 13(8), 2660; https://doi.org/10.3390/nu13082660
Received: 20 June 2021 / Revised: 28 July 2021 / Accepted: 29 July 2021 / Published: 30 July 2021
The human gut microbiome is closely linked to mental health and sleep. We aimed to verify the efficacy and safety of probiotic NVP-1704, a mixture of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98, in improving stress, depression, anxiety, and sleep disturbances, along with the measurement of some blood biomarkers. A total of 156 healthy adults with subclinical symptoms of depression, anxiety, and insomnia were retrospectively registered and randomly assigned to receive either NVP-1704 (n = 78) or a placebo (n = 78) for eight weeks. Participants completed the Stress Response Inventory, Beck’s Depression and Anxiety Inventory, Pittsburg Sleep Quality Index, and Insomnia Severity Index at baseline, at four and eight weeks of treatment. Pre- and post-treatment blood tests for biomarkers were conducted. After intervention, gut microbiota composition was quantified by pyrosequencing the bacterial 16S rRNA gene. The NVP-1704 group had a more significant reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks compared to the placebo group. Those receiving NVP-1704 also experienced an improvement in sleep quality. NVP-1704 treatment led to a decrease in serum interleukin-6 levels. Furthermore, NVP-1704 increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition. Our findings suggest that probiotic NVP-1704 could be beneficial for mental health and sleep. View Full-Text
Keywords: probiotic; gut microbiome; depression; anxiety; sleep probiotic; gut microbiome; depression; anxiety; sleep
Show Figures

Graphical abstract

MDPI and ACS Style

Lee, H.J.; Hong, J.K.; Kim, J.-K.; Kim, D.-H.; Jang, S.W.; Han, S.-W.; Yoon, I.-Y. Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2021, 13, 2660. https://doi.org/10.3390/nu13082660

AMA Style

Lee HJ, Hong JK, Kim J-K, Kim D-H, Jang SW, Han S-W, Yoon I-Y. Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021; 13(8):2660. https://doi.org/10.3390/nu13082660

Chicago/Turabian Style

Lee, Hyuk Joo, Jung Kyung Hong, Jeon-Kyung Kim, Dong-Hyun Kim, Seok Won Jang, Seung-Won Han, and In-Young Yoon. 2021. "Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial" Nutrients 13, no. 8: 2660. https://doi.org/10.3390/nu13082660

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop