Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties

Vezza, Teresa; Garrido-Mesa, José; Diez-Echave, Patricia; Hidalgo-García, Laura; Ruiz-Malagón, Antonio J.; García, Federico; Sánchez, Manuel; Toral, Marta; Romero, Miguel; Duarte, Juan; Guillamón, Enrique; Baños Arjona, Alberto; Moron, Rocío; Galvez, Julio; Rodríguez-Nogales, Alba; Rodríguez-Cabezas, María Elena

doi:10.3390/nu13082595

Open AccessArticle

Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties

by

Teresa Vezza

^1,†

,

José Garrido-Mesa

^1,†

,

Patricia Diez-Echave

^1,2,

Laura Hidalgo-García

^1,2,

Antonio J. Ruiz-Malagón

^1,2

,

Federico García

^2,3

,

Manuel Sánchez

^1,2,4,

Marta Toral

^1,2,4,

Miguel Romero

^1,2,4

,

Juan Duarte

^1,2,4

,

Enrique Guillamón

⁵,

Alberto Baños Arjona

⁵

,

Rocío Moron

^2,6,*,

Julio Galvez

^1,2,7,*

,

Alba Rodríguez-Nogales

^1,2,8,‡

and

María Elena Rodríguez-Cabezas

^1,2,‡

¹

Center for Biomedical Research (CIBM), Department of Pharmacology, University of Granada, 18071 Granada, Spain

²

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain

³

Servicio Microbiología, Hospital Universitario Clínico San Cecilio, 18100 Granada, Spain

⁴

Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 18001 Granada, Spain

⁵

DOMCA Innovative Food Solutions, DMC Research Center, 18620 Granada, Spain

⁶

Servicio Farmacia Hospitalaria, Hospital Universitario Clínico San Cecilio, 18100 Granada, Spain

⁷

Centro de Investigaciones Biomédicas en Red–Enfermedades Hepáticas y Digestivas (CIBER-EHD), Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n, 18100 Granada, Spain

⁸

Servicio de Digestivo, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

^‡

Both authors contributed equally to the supervision of the study.

Nutrients 2021, 13(8), 2595; https://doi.org/10.3390/nu13082595

Submission received: 12 July 2021 / Revised: 22 July 2021 / Accepted: 25 July 2021 / Published: 28 July 2021

(This article belongs to the Special Issue Nutrition and Metabolic Syndrome Management)

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Abstract

Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesity-associated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ẞ, Il-6, Tnf-α, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-α, Ppar-γ, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.

Keywords: cytokines; dysbiosis; glucose metabolism; lipid metabolism; microbiota; obesity; organosulfur compound

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MDPI and ACS Style

Vezza, T.; Garrido-Mesa, J.; Diez-Echave, P.; Hidalgo-García, L.; Ruiz-Malagón, A.J.; García, F.; Sánchez, M.; Toral, M.; Romero, M.; Duarte, J.; et al. Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients 2021, 13, 2595. https://doi.org/10.3390/nu13082595

AMA Style

Vezza T, Garrido-Mesa J, Diez-Echave P, Hidalgo-García L, Ruiz-Malagón AJ, García F, Sánchez M, Toral M, Romero M, Duarte J, et al. Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients. 2021; 13(8):2595. https://doi.org/10.3390/nu13082595

Chicago/Turabian Style

Vezza, Teresa, José Garrido-Mesa, Patricia Diez-Echave, Laura Hidalgo-García, Antonio J. Ruiz-Malagón, Federico García, Manuel Sánchez, Marta Toral, Miguel Romero, Juan Duarte, and et al. 2021. "Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties" Nutrients 13, no. 8: 2595. https://doi.org/10.3390/nu13082595

APA Style

Vezza, T., Garrido-Mesa, J., Diez-Echave, P., Hidalgo-García, L., Ruiz-Malagón, A. J., García, F., Sánchez, M., Toral, M., Romero, M., Duarte, J., Guillamón, E., Baños Arjona, A., Moron, R., Galvez, J., Rodríguez-Nogales, A., & Rodríguez-Cabezas, M. E. (2021). Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients, 13(8), 2595. https://doi.org/10.3390/nu13082595

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Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties

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