Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice

Morris, E. Matthew; Noland, Roberto D.; Ponte, Michael E.; Montonye, Michelle L.; Christianson, Julie A.; Stanford, John A.; Miles, John M.; Hayes, Matthew R.; Thyfault, John P.

doi:10.3390/nu13082596

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Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice

^1,2,*

¹,

³,

Julie A. Christianson

⁴,

⁵,

⁶ and

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Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA

Center for Children’s Healthy Lifestyle and Nutrition, Children’s Mercy Hospital, Kansas City, MO 64108, USA

Department of Nutrition & Exercise Physiology, University of Missouri, Columbia, MO 65211, USA

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Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA

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Department of Internal Medicine—Division of Endocrinology and Metabolism, University of Kansas Medical Center, Kansas City, KS 66160, USA

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Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA

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Kansas City VA Medical Center-Research Service, Kansas City, MO 64128, USA

Author to whom correspondence should be addressed.

Academic Editor: Manuela Merli

Nutrients 2021, 13(8), 2596; https://doi.org/10.3390/nu13082596

Received: 2 June 2021 / Revised: 21 July 2021 / Accepted: 24 July 2021 / Published: 28 July 2021

(This article belongs to the Section Nutrition and Metabolism)

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Abstract

The central integration of peripheral neural signals is one mechanism by which systemic energy homeostasis is regulated. Previously, increased acute food intake following the chemical reduction of hepatic fatty acid oxidation and ATP levels was prevented by common hepatic branch vagotomy (HBV). However, possible offsite actions of the chemical compounds confound the precise role of liver energy metabolism. Herein, we used a hepatocyte PGC1a heterozygous (LPGC1a) mouse model, with associated reductions in mitochondrial fatty acid oxidation and respiratory capacity, to assess the role of liver energy metabolism in systemic energy homeostasis. LPGC1a male, but not female, mice had a 70% greater high-fat/high-sucrose (HFHS) diet-induced weight gain compared to wildtype (WT) mice (p < 0.05). The greater weight gain was associated with altered feeding behavior and lower activity energy expenditure during the HFHS diet in LPGC1a males. WT and LPGC1a mice underwent sham surgery or HBV to assess whether vagal signaling was involved in the HFHS-induced weight gain of male LPGC1a mice. HBV increased HFHS-induced weight gain (85%, p < 0.05) in male WT mice, but not LPGC1a mice. These data demonstrate a sex-specific role of reduced liver energy metabolism in acute diet-induced weight gain, and the need for a more nuanced assessment of the role of vagal signaling in short-term diet-induced weight gain. View Full-Text

Keywords: energy homeostasis; weight gain; food intake; energy expenditure; liver; mitochondria

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MDPI and ACS Style

Morris, E.M.; Noland, R.D.; Ponte, M.E.; Montonye, M.L.; Christianson, J.A.; Stanford, J.A.; Miles, J.M.; Hayes, M.R.; Thyfault, J.P. Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice. Nutrients 2021, 13, 2596. https://doi.org/10.3390/nu13082596

AMA Style

Morris EM, Noland RD, Ponte ME, Montonye ML, Christianson JA, Stanford JA, Miles JM, Hayes MR, Thyfault JP. Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice. Nutrients. 2021; 13(8):2596. https://doi.org/10.3390/nu13082596

Chicago/Turabian Style

Morris, E. Matthew, Roberto D. Noland, Michael E. Ponte, Michelle L. Montonye, Julie A. Christianson, John A. Stanford, John M. Miles, Matthew R. Hayes, and John P. Thyfault. 2021. "Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice" Nutrients 13, no. 8: 2596. https://doi.org/10.3390/nu13082596

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Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice

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