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Review

Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
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Academic Editor: Adam Rose
Nutrients 2021, 13(8), 2592; https://doi.org/10.3390/nu13082592
Received: 13 June 2021 / Revised: 20 July 2021 / Accepted: 20 July 2021 / Published: 28 July 2021
Threonine (Thr), an essential amino acid for animals and the limiting amino acid in swine and poultry diets, which plays a vital role in the modulation of nutritional metabolism, macromolecular biosynthesis, and gut homeostasis. Current evidence supports that the supplementation of Thr leads to benefits in terms of energy metabolism. Threonine is not only an important component of gastrointestinal mucin, but also acts as a nutritional modulator that influences the intestinal immune system via complex signaling networks, particularly mitogen-activated protein kinase (MAPK) and the target of the rapamycin (TOR) signal pathway. Threonine is also recognized as an indispensable nutrient for cell growth and proliferation. Hence, optimization of Thr requirement may exert a favorable impact on the factors linked to health and diseases in animals. This review focuses on the latest reports of Thr in metabolic pathways and nutritional regulation, as well as the relationship between Thr and relevant physiological functions. View Full-Text
Keywords: threonine; metabolism; physiological effects; nutrition; intestinal health threonine; metabolism; physiological effects; nutrition; intestinal health
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MDPI and ACS Style

Tang, Q.; Tan, P.; Ma, N.; Ma, X. Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism. Nutrients 2021, 13, 2592. https://doi.org/10.3390/nu13082592

AMA Style

Tang Q, Tan P, Ma N, Ma X. Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism. Nutrients. 2021; 13(8):2592. https://doi.org/10.3390/nu13082592

Chicago/Turabian Style

Tang, Qi, Peng Tan, Ning Ma, and Xi Ma. 2021. "Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism" Nutrients 13, no. 8: 2592. https://doi.org/10.3390/nu13082592

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