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Review

Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets—A Narrative Review

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Institute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary
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Department of Biochemistry and Medical Chemistry, Medical School, University of Pecs, 7624 Pecs, Hungary
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Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary
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Institute of Bioanalysis, Medical School, University of Pecs, 7624 Pecs, Hungary
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Szentagothai Research Center, University of Pecs, 7624 Pecs, Hungary
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Institute for Translational Medicine, Medical School, University of Pecs, 7624 Pecs, Hungary
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Institute of Health Insurance, Faculty of Health Sciences, University of Pecs, 7621 Pecs, Hungary
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2nd Department of Internal Medicine and Nephrology Centre, Clinical Centre, University of Pecs, 7624 Pecs, Hungary
*
Author to whom correspondence should be addressed.
Academic Editors: Winston Craig and Dragan Milenkovic
Nutrients 2021, 13(8), 2593; https://doi.org/10.3390/nu13082593
Received: 31 May 2021 / Revised: 26 July 2021 / Accepted: 27 July 2021 / Published: 28 July 2021
Plant-based diets are becoming more popular for many reasons, and epidemiological as well as clinical data also suggest that a well-balanced vegan diet can be adopted for the prevention, and in some cases, in the treatment of many diseases. In this narrative review, we provide an overview of the relationships between these diets and various conditions and their potential biochemical background. As whole plant foods are very rich in food-derived antioxidants and other phytochemicals, they have many positive physiological effects on different aspects of health. In the background of the beneficial health effects, several biochemical processes could stand, including the reduced formation of trimethylamine oxide (TMAO) or decreased serum insulin-like growth factor 1 (IGF-1) levels and altered signaling pathways such as mechanistic target of rapamycin (mTOR). In addition, the composition of plant-based diets may play a role in preventing lipotoxicity, avoiding N-glycolylneuraminic acid (Neu5Gc), and reducing foodborne endotoxin intake. In this article, we attempt to draw attention to the growing knowledge about these diets and provide starting points for further research. View Full-Text
Keywords: vegan; plant-based diet; antioxidant; lipotoxicity; TMAO; IGF-1; mTOR; Neu5Gc; endotoxemia vegan; plant-based diet; antioxidant; lipotoxicity; TMAO; IGF-1; mTOR; Neu5Gc; endotoxemia
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MDPI and ACS Style

Szabo, Z.; Koczka, V.; Marosvolgyi, T.; Szabo, E.; Frank, E.; Polyak, E.; Fekete, K.; Erdelyi, A.; Verzar, Z.; Figler, M. Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets—A Narrative Review. Nutrients 2021, 13, 2593. https://doi.org/10.3390/nu13082593

AMA Style

Szabo Z, Koczka V, Marosvolgyi T, Szabo E, Frank E, Polyak E, Fekete K, Erdelyi A, Verzar Z, Figler M. Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets—A Narrative Review. Nutrients. 2021; 13(8):2593. https://doi.org/10.3390/nu13082593

Chicago/Turabian Style

Szabo, Zoltan, Viktor Koczka, Tamas Marosvolgyi, Eva Szabo, Eszter Frank, Eva Polyak, Kata Fekete, Attila Erdelyi, Zsofia Verzar, and Maria Figler. 2021. "Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets—A Narrative Review" Nutrients 13, no. 8: 2593. https://doi.org/10.3390/nu13082593

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