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Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach

by 1,2, 1,3,†, 2,4,†, 1, 2,4,5,*, 6,* and 1,*
1
Centre for Marine Bioproducts Development, College of Medicine & Public Health, Flinders University, Bedford Park, Adelaide, SA 5042, Australia
2
The Basil Hetzel Institute for Translational Health Research, Adelaide, SA 5011, Australia
3
Shanxi University of Traditional Chinese Medicine, Taiyuan 030600, China
4
Discipline of Surgery, Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5000, Australia
5
AusHealth Corporate Pty Ltd., Adelaide, SA 5032, Australia
6
Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Marek Kieliszek
Nutrients 2021, 13(8), 2564; https://doi.org/10.3390/nu13082564
Received: 3 June 2021 / Revised: 13 July 2021 / Accepted: 21 July 2021 / Published: 27 July 2021
Astragalus root (Huang Qi) and Shiitake mushrooms (Lentinus edodes) are both considered medicinal foods and are frequently used in traditional Chinese medicine due to their anticancer and immunomodulating properties. Here, the scientific literatures describing evidence for the anticancer and immunogenic properties of Shiitake and Astragalus were reviewed. Based on our experimental data, the potential to develop medicinal food with combined bioactivities was assessed using Shiitake mushrooms grown over Astragalus beds in a proprietary manufacturing process, as a novel cancer prevention approach. Notably, our data suggest that this new manufacturing process can result in transfer and increased bioavailability of Astragalus polysaccharides with therapeutic potential into edible Shiitake. Further research efforts are required to validate the therapeutic potential of this new Hengshan Astragalus Shiitake medicinal food. View Full-Text
Keywords: Astragalus; Shiitake; Hengshan Astragalus Shiitake; cancer immunology; medicinal food; bioactive Astragalus; Shiitake; Hengshan Astragalus Shiitake; cancer immunology; medicinal food; bioactive
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MDPI and ACS Style

Balakrishnan, B.; Liang, Q.; Fenix, K.; Tamang, B.; Hauben, E.; Ma, L.; Zhang, W. Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach. Nutrients 2021, 13, 2564. https://doi.org/10.3390/nu13082564

AMA Style

Balakrishnan B, Liang Q, Fenix K, Tamang B, Hauben E, Ma L, Zhang W. Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach. Nutrients. 2021; 13(8):2564. https://doi.org/10.3390/nu13082564

Chicago/Turabian Style

Balakrishnan, Biju, Qi Liang, Kevin Fenix, Bunu Tamang, Ehud Hauben, Linlin Ma, and Wei Zhang. 2021. "Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach" Nutrients 13, no. 8: 2564. https://doi.org/10.3390/nu13082564

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