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Review

Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review

1
Food, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada
2
Healthy Starts, BC Children’s Hospital Research Institute, 938 West 28th Ave, Vancouver, BC V5Z 4H4, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Teresa Partearroyo
Nutrients 2021, 13(7), 2340; https://doi.org/10.3390/nu13072340
Received: 8 June 2021 / Revised: 5 July 2021 / Accepted: 6 July 2021 / Published: 9 July 2021
(This article belongs to the Special Issue Health Benefits of Iron and Folic Acid Supplementation)
Oral contraceptive use has been associated with decreased menstrual blood losses; thus, can independently reduce the risk of anemia and iron deficiency in women. Manufacturers have recently started to include supplemental iron in the non-hormonal placebo tablets of some contraceptives. The aims of this narrative review are: (i) to describe the relationship between oral contraceptive use and both anemia and iron status in women; (ii) to describe the current formulations of iron-containing oral contraceptives (ICOC) available on the market; and (iii) to systematically review the existing literature on the effect of ICOC on biomarkers of anemia and iron status in women. We discovered 21 brands of ICOC, most commonly including 25 mg elemental iron as ferrous fumarate, for seven days, per monthly tablet package. Our search identified one randomized trial evaluating the effectiveness of ICOC use compared to two non-ICOC on increasing hemoglobin (Hb) and iron status biomarker concentrations in women; whereafter 12 months of contraception use, there were no significant differences in Hb concentration nor markers of iron status between the groups. ICOC has the potential to be a cost-effective solution to address both family planning needs and iron deficiency anemia. Yet, more rigorous trials evaluating the effectiveness of ICOC on improving markers of anemia and iron deficiency, as well as investigating the safety of its consumption among iron-replete populations, are warranted. View Full-Text
Keywords: iron; ferrous iron; ferritin; iron deficiency; iron-containing oral contraceptives; hemoglobin; anemia; oral contraceptive; contraceptive; birth control iron; ferrous iron; ferritin; iron deficiency; iron-containing oral contraceptives; hemoglobin; anemia; oral contraceptive; contraceptive; birth control
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MDPI and ACS Style

Fischer, J.A.J.; Sasai, C.S.; Karakochuk, C.D. Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review. Nutrients 2021, 13, 2340. https://doi.org/10.3390/nu13072340

AMA Style

Fischer JAJ, Sasai CS, Karakochuk CD. Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review. Nutrients. 2021; 13(7):2340. https://doi.org/10.3390/nu13072340

Chicago/Turabian Style

Fischer, Jordie A.J., Carolina S. Sasai, and Crystal D. Karakochuk 2021. "Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review" Nutrients 13, no. 7: 2340. https://doi.org/10.3390/nu13072340

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