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Nutrients
Volume 13
Issue 6
10.3390/nu13062010
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Article

Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice

by
Wenwei Lu
1,2,3,
Yadan Deng
1,2,
Zhifeng Fang
1,2,
Qixiao Zhai
1,2,
Shumao Cui
1,2,
Jianxin Zhao
1,2,
Wei Chen
1,2,3 and
Hao Zhang
1,2,3,*
1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
2
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
3
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(6), 2010; https://doi.org/10.3390/nu13062010
Submission received: 20 May 2021 / Revised: 2 June 2021 / Accepted: 6 June 2021 / Published: 11 June 2021
(This article belongs to the Special Issue Gut Microbiota in Human Health and Diseases)
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Abstract

Psoriasis is an immune-mediated systemic disease that may be treated with probiotics. In this study, probiotic strains that could or could not decrease interleukin (IL)-17 levels were applied to imiquimod (IMQ)-induced psoriasis-like mice via oral administration. Bifidobacterium adolescentis CCFM667, B. breve CCFM1078, Lacticaseibacillus paracasei CCFM1074, and Limosilactobacillus reuteri CCFM1132 ameliorated psoriasis-like pathological characteristics and suppressed the release of IL-23/T helper cell 17 (Th17) axis-related inflammatory cytokines, whereas B. animalis CCFM1148, L. paracasei CCFM1147, and L. reuteri CCFM1040 neither alleviated the pathological characteristics nor reduced the levels of inflammatory cytokines. All effective strains increased the contents of short-chain fatty acids, which were negatively correlated with the levels of inflammatory cytokines. By performing 16S rRNA gene sequencing, the diversity of gut microbiota in psoriasis-like mice was found to decrease, but all effective strains made some specific changes to the composition of gut microbiota compared to the ineffective strains. Furthermore, except for B. breve CCFM1078, all other effective strains decreased the abundance of the family Rikenellaceae, which was positively correlated with psoriasis-like pathological characteristics and was negatively correlated with propionate levels. These findings demonstrated effects of strain-specificity, and how probiotics ameliorated psoriasis and provide new possibilities for the treatment of psoriasis.
Keywords: psoriasis; probiotics; IL-23/Th17 axis; gut microbiota psoriasis; probiotics; IL-23/Th17 axis; gut microbiota
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MDPI and ACS Style

Lu, W.; Deng, Y.; Fang, Z.; Zhai, Q.; Cui, S.; Zhao, J.; Chen, W.; Zhang, H. Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice. Nutrients 2021, 13, 2010. https://doi.org/10.3390/nu13062010

AMA Style

Lu W, Deng Y, Fang Z, Zhai Q, Cui S, Zhao J, Chen W, Zhang H. Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice. Nutrients. 2021; 13(6):2010. https://doi.org/10.3390/nu13062010

Chicago/Turabian Style

Lu, Wenwei, Yadan Deng, Zhifeng Fang, Qixiao Zhai, Shumao Cui, Jianxin Zhao, Wei Chen, and Hao Zhang. 2021. "Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice" Nutrients 13, no. 6: 2010. https://doi.org/10.3390/nu13062010

APA Style

Lu, W., Deng, Y., Fang, Z., Zhai, Q., Cui, S., Zhao, J., Chen, W., & Zhang, H. (2021). Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice. Nutrients, 13(6), 2010. https://doi.org/10.3390/nu13062010

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