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Volume 13
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10.3390/nu13061768
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Communication

Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study

by
Shirin Pourafshar
1,*,†,
Mira Nicchitta
2,3,4,†,
Crystal C. Tyson
3,
Laura P. Svetkey
3,5,
David L. Corcoran
6,
James R. Bain
3,5,
Michael J. Muehlbauer
5,
Olga Ilkayeva
3,5,
Thomas M. O’Connell
5,7,
Pao-Hwa Lin
3,5,† and
Julia J. Scialla
1,3,8,†
1
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22903, USA
2
College of William and Mary, Williamsburg, VA 23185, USA
3
Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
4
Department of Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA
5
Duke Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC 27701, USA
6
Center for Genomics and Computational Biology, School of Medicine, Duke University, Durham, NC 27708, USA
7
Department of Otolaryngology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
8
Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2021, 13(6), 1768; https://doi.org/10.3390/nu13061768
Submission received: 26 April 2021 / Revised: 10 May 2021 / Accepted: 20 May 2021 / Published: 22 May 2021
(This article belongs to the Section Nutrition and Metabolism)
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Abstract

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet.
Keywords: nutrition; polyphenols; blood pressure; DASH; metabolomics nutrition; polyphenols; blood pressure; DASH; metabolomics
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MDPI and ACS Style

Pourafshar, S.; Nicchitta, M.; Tyson, C.C.; Svetkey, L.P.; Corcoran, D.L.; Bain, J.R.; Muehlbauer, M.J.; Ilkayeva, O.; O’Connell, T.M.; Lin, P.-H.; et al. Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study. Nutrients 2021, 13, 1768. https://doi.org/10.3390/nu13061768

AMA Style

Pourafshar S, Nicchitta M, Tyson CC, Svetkey LP, Corcoran DL, Bain JR, Muehlbauer MJ, Ilkayeva O, O’Connell TM, Lin P-H, et al. Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study. Nutrients. 2021; 13(6):1768. https://doi.org/10.3390/nu13061768

Chicago/Turabian Style

Pourafshar, Shirin, Mira Nicchitta, Crystal C. Tyson, Laura P. Svetkey, David L. Corcoran, James R. Bain, Michael J. Muehlbauer, Olga Ilkayeva, Thomas M. O’Connell, Pao-Hwa Lin, and et al. 2021. "Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study" Nutrients 13, no. 6: 1768. https://doi.org/10.3390/nu13061768

APA Style

Pourafshar, S., Nicchitta, M., Tyson, C. C., Svetkey, L. P., Corcoran, D. L., Bain, J. R., Muehlbauer, M. J., Ilkayeva, O., O’Connell, T. M., Lin, P.-H., & Scialla, J. J. (2021). Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study. Nutrients, 13(6), 1768. https://doi.org/10.3390/nu13061768

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