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Open AccessReview

Effects of Anthocyanin on Intestinal Health: A Systematic Review

1
Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-000, MG, Brazil
2
Empresa Brasileira de Pesquisa e Agropecuária (EMBRAPA), Sete Lagoas 35701-970, MG, Brazil
3
Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel Goni
Nutrients 2021, 13(4), 1331; https://doi.org/10.3390/nu13041331
Received: 10 March 2021 / Revised: 12 April 2021 / Accepted: 14 April 2021 / Published: 17 April 2021
Intestinal health relies on the association between the mucosal immune system, intestinal barrier and gut microbiota. Bioactive components that affect the gut microbiota composition, epithelial physical barrier and intestinal morphology were previously studied. The current systematic review evaluated evidence of anthocyanin effects and the ability to improve gut microbiota composition, their metabolites and parameters of the physical barrier; this was conducted in order to answer the question: “Does food source or extract of anthocyanin promote changes on intestinal parameters?”. The data analysis was conducted following the PRISMA guidelines with the search performed at PubMed, Cochrane and Scopus databases for experimental studies, and the risk of bias was assessed by the SYRCLE tool. Twenty-seven studies performed in animal models were included, and evaluated for limitations in heterogeneity, methodologies, absence of information regarding allocation process and investigators’ blinding. The data were analyzed, and the anthocyanin supplementation demonstrated positive effects on intestinal health. The main results identified were an increase of Bacteroidetes and a decrease of Firmicutes, an increase of short chain fatty acids production, a decrease of intestinal pH and intestinal permeability, an increase of the number of goblet cells and tight junction proteins and villi improvement in length or height. Thus, the anthocyanin supplementation has a potential effect to improve the intestinal health. PROSPERO (CRD42020204835). View Full-Text
Keywords: microbiota; polyphenols; short chain fatty acids; intestinal barrier microbiota; polyphenols; short chain fatty acids; intestinal barrier
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MDPI and ACS Style

Verediano, T.A.; Stampini Duarte Martino, H.; Dias Paes, M.C.; Tako, E. Effects of Anthocyanin on Intestinal Health: A Systematic Review. Nutrients 2021, 13, 1331. https://doi.org/10.3390/nu13041331

AMA Style

Verediano TA, Stampini Duarte Martino H, Dias Paes MC, Tako E. Effects of Anthocyanin on Intestinal Health: A Systematic Review. Nutrients. 2021; 13(4):1331. https://doi.org/10.3390/nu13041331

Chicago/Turabian Style

Verediano, Thaísa A.; Stampini Duarte Martino, Hércia; Dias Paes, Maria C.; Tako, Elad. 2021. "Effects of Anthocyanin on Intestinal Health: A Systematic Review" Nutrients 13, no. 4: 1331. https://doi.org/10.3390/nu13041331

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