Next Article in Journal
Pork Liver Pâté Enriched with Persimmon Coproducts: Effect of In Vitro Gastrointestinal Digestion on Its Fatty Acid and Polyphenol Profile Stability
Previous Article in Journal
The Sleep and Recovery Practices of Athletes
Previous Article in Special Issue
Rosa canina L. Can Restore Endoplasmic Reticulum Alterations, Protein Trafficking and Membrane Integrity in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Phenotype
Open AccessReview

Effects of Anthocyanin on Intestinal Health: A Systematic Review

Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-000, MG, Brazil
Empresa Brasileira de Pesquisa e Agropecuária (EMBRAPA), Sete Lagoas 35701-970, MG, Brazil
Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA
Author to whom correspondence should be addressed.
Academic Editor: Isabel Goni
Nutrients 2021, 13(4), 1331;
Received: 10 March 2021 / Revised: 12 April 2021 / Accepted: 14 April 2021 / Published: 17 April 2021
Intestinal health relies on the association between the mucosal immune system, intestinal barrier and gut microbiota. Bioactive components that affect the gut microbiota composition, epithelial physical barrier and intestinal morphology were previously studied. The current systematic review evaluated evidence of anthocyanin effects and the ability to improve gut microbiota composition, their metabolites and parameters of the physical barrier; this was conducted in order to answer the question: “Does food source or extract of anthocyanin promote changes on intestinal parameters?”. The data analysis was conducted following the PRISMA guidelines with the search performed at PubMed, Cochrane and Scopus databases for experimental studies, and the risk of bias was assessed by the SYRCLE tool. Twenty-seven studies performed in animal models were included, and evaluated for limitations in heterogeneity, methodologies, absence of information regarding allocation process and investigators’ blinding. The data were analyzed, and the anthocyanin supplementation demonstrated positive effects on intestinal health. The main results identified were an increase of Bacteroidetes and a decrease of Firmicutes, an increase of short chain fatty acids production, a decrease of intestinal pH and intestinal permeability, an increase of the number of goblet cells and tight junction proteins and villi improvement in length or height. Thus, the anthocyanin supplementation has a potential effect to improve the intestinal health. PROSPERO (CRD42020204835). View Full-Text
Keywords: microbiota; polyphenols; short chain fatty acids; intestinal barrier microbiota; polyphenols; short chain fatty acids; intestinal barrier
Show Figures

Figure 1

MDPI and ACS Style

Verediano, T.A.; Stampini Duarte Martino, H.; Dias Paes, M.C.; Tako, E. Effects of Anthocyanin on Intestinal Health: A Systematic Review. Nutrients 2021, 13, 1331.

AMA Style

Verediano TA, Stampini Duarte Martino H, Dias Paes MC, Tako E. Effects of Anthocyanin on Intestinal Health: A Systematic Review. Nutrients. 2021; 13(4):1331.

Chicago/Turabian Style

Verediano, Thaísa A.; Stampini Duarte Martino, Hércia; Dias Paes, Maria C.; Tako, Elad. 2021. "Effects of Anthocyanin on Intestinal Health: A Systematic Review" Nutrients 13, no. 4: 1331.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop