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Open AccessArticle

Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein

Department of Clinical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-210 Gdańsk, Poland
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Academic Editors: John Mamo, Ryu Takechi and Virginie Lam
Nutrients 2021, 13(4), 1224; https://doi.org/10.3390/nu13041224
Received: 26 February 2021 / Revised: 31 March 2021 / Accepted: 6 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
Impaired triglyceride-rich lipoprotein plasma catabolism is considered the most important factor for hypertriglyceridemia development. The aim of this study was to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL)-triglyceride lipolysis and the role of high-density lipoprotein (HDL) in this process. Subjects with no history of cardiovascular disease (CVD) and untreated with lipid-lowering agents were recruited into the study and divided into normolipidemic, hypercholesterolemic, and hyperlipidemic groups. VLDL was isolated from serum and incubated with LPL in the absence or presence of HDL. For the hypercholesterolemic and hyperlipidemic groups, a significantly lower percentage of hydrolyzed VLDL-triglyceride was achieved compared to the normolipidemic group (p < 0.01). HDL enhanced the lipolysis efficiency in the hypercholesterolemic and hyperlipidemic groups on average by ~7% (p < 0.001). The lowest electrophoretic mobility of the VLDL remnants indicating the most effective lipolysis was obtained in the normolipidemic group (p < 0.05). HDL presence significantly reduced the electrophoretic mobility of the VLDL remnants for the hypercholesterolemic and hyperlipidemic groups (p < 0.05). The results of our study indicate that VLDL obtained from hypercholesterolemic and hyperlipidemic subjects are more resistant to lipolysis and are additional evidence of the need for early implementation of hypocholesterolemic treatment, already in asymptomatic CVD subjects. View Full-Text
Keywords: high-density lipoprotein; hypercholesterolemia; hypertriglyceridemia; lipolysis; lipoprotein lipase; triglycerides; very-low-density lipoprotein high-density lipoprotein; hypercholesterolemia; hypertriglyceridemia; lipolysis; lipoprotein lipase; triglycerides; very-low-density lipoprotein
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MDPI and ACS Style

Wieczorek, E.; Ćwiklińska, A.; Kuchta, A.; Kortas-Stempak, B.; Gliwińska, A.; Jankowski, M. Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein. Nutrients 2021, 13, 1224. https://doi.org/10.3390/nu13041224

AMA Style

Wieczorek E, Ćwiklińska A, Kuchta A, Kortas-Stempak B, Gliwińska A, Jankowski M. Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein. Nutrients. 2021; 13(4):1224. https://doi.org/10.3390/nu13041224

Chicago/Turabian Style

Wieczorek, Ewa; Ćwiklińska, Agnieszka; Kuchta, Agnieszka; Kortas-Stempak, Barbara; Gliwińska, Anna; Jankowski, Maciej. 2021. "Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein" Nutrients 13, no. 4: 1224. https://doi.org/10.3390/nu13041224

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