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Open AccessFeature PaperArticle

Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model

1
SOPAM, U1063, Inserm, SFR Interactions Cellulaires et Applications Thérapeutiques Université D’Angers, 49 933 Angers, France
2
UMR 1280 Physiopathologie des Adaptations Nutritionnelles (PhAN), INRAE, Université de Nantes, 44 093 Nantes, France
3
Centre de Recherche en Nutrition Humaine Ouest, 44 093 Nantes, France
4
EA 3859, Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques (HIFIH), Université d’Angers, 49 933 Angers, France
5
Institut Agro, Université d’Angers, INRAE, IRHS, SFR QUASAV, 49 045 Angers, France
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Academic Editor: Sara Baldassano
Nutrients 2021, 13(4), 1181; https://doi.org/10.3390/nu13041181
Received: 16 February 2021 / Revised: 29 March 2021 / Accepted: 31 March 2021 / Published: 2 April 2021
(This article belongs to the Special Issue Nutritional Regulation of Lipid Metabolism and Health)
Epidemiological studies have shown that carrot consumption may be associated with a lower risk of developing several metabolic dysfunctions. Our group previously determined that the Bolero (Bo) carrot variety exhibited vascular and hepatic tropism using cellular models of cardiometabolic diseases. The present study evaluated the potential metabolic and cardiovascular protective effect of Bo, grown under two conditions (standard and biotic stress conditions (BoBS)), in apolipoprotein E-knockout (ApoE−/−) mice fed with high fat diet (HFD). Effects on metabolic/hemodynamic parameters and on atherosclerotic lesions have been assessed. Both Bo and BoBS decreased plasma triglyceride and expression levels of genes implicated in hepatic de novo lipogenesis and lipid oxidation. BoBS supplementation decreased body weight gain, secretion of very-low-density lipoprotein, and increased cecal propionate content. Interestingly, Bo and BoBS supplementation improved hemodynamic parameters by decreasing systolic, diastolic, and mean blood pressure. Moreover, Bo improved cardiac output. Finally, Bo and BoBS substantially reduced the aortic root lesion area. These results showed that Bo and BoBS enriched diets corrected most of the metabolic and cardiovascular disorders in an atherosclerosis-prone genetic mouse model and may therefore represent an interesting nutritional approach for the prevention of cardiovascular diseases. View Full-Text
Keywords: carrot supplementation; hemodynamic parameter; atherosclerosis; high fat diet; ApoE−/− carrot supplementation; hemodynamic parameter; atherosclerosis; high fat diet; ApoE−/−
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MDPI and ACS Style

Soleti, R.; Coué, M.; Trenteseaux, C.; Hilairet, G.; Fizanne, L.; Kasbi-Chadli, F.; Mallegol, P.; Chaigneau, J.; Boursier, J.; Krempf, M.; Geoffriau, E.; Andriantsitohaina, R.; Ouguerram, K. Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model. Nutrients 2021, 13, 1181. https://doi.org/10.3390/nu13041181

AMA Style

Soleti R, Coué M, Trenteseaux C, Hilairet G, Fizanne L, Kasbi-Chadli F, Mallegol P, Chaigneau J, Boursier J, Krempf M, Geoffriau E, Andriantsitohaina R, Ouguerram K. Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model. Nutrients. 2021; 13(4):1181. https://doi.org/10.3390/nu13041181

Chicago/Turabian Style

Soleti, Raffaella; Coué, Marine; Trenteseaux, Charlotte; Hilairet, Gregory; Fizanne, Lionel; Kasbi-Chadli, Fatima; Mallegol, Patricia; Chaigneau, Julien; Boursier, Jerome; Krempf, Michel; Geoffriau, Emmanuel; Andriantsitohaina, Ramaroson; Ouguerram, Khadija. 2021. "Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model" Nutrients 13, no. 4: 1181. https://doi.org/10.3390/nu13041181

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