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Article

Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999–2004

1
Ramboll U.S. Consulting, Inc., Monroe, LA 71201, USA
2
Food & Nutrition Database Research, Inc., Bangor, PA 18013, USA
3
Ramboll U.S. Consulting, Inc., 3214 Charles B. Root Wynd, Suite 130, Raleigh, NC 27612, USA
*
Author to whom correspondence should be addressed.
Academic Editor: A. Catharine Ross
Nutrients 2021, 13(3), 813; https://doi.org/10.3390/nu13030813
Received: 21 January 2021 / Revised: 24 February 2021 / Accepted: 24 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Effects of Nutrients on Immune and Inflammatory Responses)
Treatment with prebiotics, a type of dietary fiber, was recently shown to increase antibody concentrations following influenza vaccination in a meta-analysis of clinical trials. In observational epidemiologic studies it is not possible to estimate intake of prebiotics, but quantifying intake of dietary fiber is routine. Our objective was to investigate the potential effect of dietary fiber on immunogenicity. We examined serum antibody concentrations (Measles, Mumps, Rubella, and Varicella) in relation to dietary fiber in more than 12,000 subjects in the U.S. National Health and Nutrition Examination Survey (NHANES) for the period 1999–2004. Data from one (1999–2002) or two (2003–2004) dietary recalls were used to calculate fiber intake. For Mumps the adjusted percentage difference in antibody concentration per interquartile range intake in energy-adjusted dietary fiber was 6.34% (95% confidence interval, 3.10, 9.68). Fiber from grain-based foods was more positively associated than fiber from other fiber-containing food groups. The association was slightly larger among subgroups with higher fiber intake, greater interquartile range in fiber intake, and less measurement error. Furthermore, based on the reliability of the diet recalls in 2003–2004, we calculated that the percentage difference per interquartile increment was substantially attenuated by measurement error. Dietary fiber may have a favorable influence on the immunogenicity of some vaccines or natural infections. View Full-Text
Keywords: dietary fiber; immunogenicity; antibodies; Mumps; nutrition surveys dietary fiber; immunogenicity; antibodies; Mumps; nutrition surveys
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MDPI and ACS Style

Van Landingham, C.B.; Keast, D.R.; Longnecker, M.P. Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999–2004. Nutrients 2021, 13, 813. https://doi.org/10.3390/nu13030813

AMA Style

Van Landingham CB, Keast DR, Longnecker MP. Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999–2004. Nutrients. 2021; 13(3):813. https://doi.org/10.3390/nu13030813

Chicago/Turabian Style

Van Landingham, Cynthia B., Debra R. Keast, and Matthew P. Longnecker 2021. "Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999–2004" Nutrients 13, no. 3: 813. https://doi.org/10.3390/nu13030813

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