Vitamin D and Lung Outcomes in Elderly COVID-19 Patients
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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COVID-19 | CONTROLS | p | |
---|---|---|---|
Age (years, mean ± SD) | 76 ± 13 | 76 ± 13 | 0.814 |
Disease duration (days, mean ± SD) | 13.1 ± 13 | - | - |
Male/Female | 30/35 | 30/35 | - |
Body mass index (kg/m2) | 26.3 | 25.4 | 0.634 |
Ethnicity: Caucasian | 65/65 | 65/65 | 0.931 |
Died during hospitalization | 10/65 | - | - |
Recovery time (days, mean ± SD) | 33 ± 14 | - | - |
Smoking status | 4/65 | 4/65 | 0.891 |
Arterial hypertension | 35/65 (54%) | 36/65 (55%) | 0.281 |
Previous cardiac/cerebral ischemic vasculopathy | 14/65 (21%) | 6/65 (11%) | 0.357 |
Neoplasms | 11/65 (16%) | 5/65 (8%) | 0.091 |
Recent hip or vertebral fracture | 12/65 (18%) | 11/65 (17%) | 0.916 |
Diabetes | 10/65 (15%) | 9/65 (14%) | 0.737 |
Chronic atrial fibrillation | 11/65 (17%) | 11/65 (17%) | 0.492 |
Chronic obstructive pulmonary disease | 8/65(12%) | 3/65 (3%) | 0.213 |
Chronic kidney disease | 5/65 (8%) | 4/65 (6%) | 0.652 |
Dysthyroidism | 4/65 (6%) | 5/65 (8%) | 0.458 |
Colic diverticulosis | 5/65 (8%) | 2/65 (3%) | 0.223 |
Chronic arthritis (rheumatoid or psoriatic) | 2/65 (3%) | 7/65 (11%) | 0.049 |
Epilepsy | 2/65 (3%) | 4/65 (6%) | 0.296 |
Allergic asthma | 1/65 (2%) | 2/65 (3%) | 0.414 |
Liver cirrhosis | 1/65 (2%) | 3/65 (5%) | 0.243 |
Hepatitis B infection | 1/65 (2%) | 1/65 (2%) | 0.892 |
No comorbidities | 7/65 (11%) | 10/65 (15%) | 0.490 |
One comorbidity | 17/65 (26%) | 19/65 (29%) | 0.749 |
Two comorbidities | 24/65 (37%) | 22/65 (34%) | 0.647 |
Three comorbidities | 13/65 (20%) | 11/65 (17) | 0.547 |
Four or more comorbidities | 4/65 (6%) | 3/65 (5%) | 0.616 |
Vitamin D supplementation | 22/65 (34%) | 44/65 (68%) | 0.015 |
COVID-19 | Normal Range | |
---|---|---|
SO2 (%) | 92 (4) | 95–99 |
PaO2 (mmHg) | 69 (20) | 83–108 |
PaCO2 (mmHg) | 37 (7) | 35–48 |
FiO2 (%) | 31 (36) | 21 |
PaO2/FiO2 | 211 (199) | >300 |
D-dimer (mcg/L) | 1078 (1071) | 0–500 |
C-reactive protein (mg/L) | 39 (78) | 0–5 |
Ferritin (mcg/L) | 562 (746) | 30–400 |
LDH—lactate dehydrogenase (UI/L) | 259 (117) | 135–225 |
White blood cells (×109/L) | 5.9 (4.2) | 4.5–9.8 |
Lymphocytes (×109/L) | 0.9 (0.6) | 1.1–4.8 |
Haemoglobin (g/L) | 11.3 (2.9) | 12–17.5 |
Platelets (×109/L) | 218 (166) | 130–430 |
GOT—glutamic oxaloacetic transaminase (UI/L) | 34 (21) | 0–40 |
GPT—glutamic-pyruvate transaminase (UI/L) | 29 (21) | 0–40 |
Creatinine (mg/dL) | 0.9 (0.4) | 0.6–1.0 |
Calcium (mg/dL) | 8.7 (0.5) | 8.5–11.0 |
Phosphorus (mg/dL) | 3.2 (1.1) | 2.5–4.5 |
PTH—parathyroid hormone (ng/L) | 51 (40) | 6.5–36.8 |
COVID-19 | CNT | Statistical Significance | |
---|---|---|---|
All subjects | 7.9 (15) | 16.3 (19) | p = 0.001 |
Died/Survived | 3.0 (8)/8.4 (18) | - | p = 0.046 |
Male | 7.0 (12) * | 13.6 (20) * | p = 0.021 |
Female | 9.3 (20) * | 18.3 (19) * | p = 0.0049 |
Outcome | Predictors | Beta (95% CI) | p Value |
---|---|---|---|
PaO2/FiO2 (log) | 25OHD (ng/mL) (log) | 0.17 (0.01, 0.33) | 0.033 |
Sex (female) | −0.02 (−0.31, 0.27) | 0.889 | |
Age (years) | −0.00 (−0.01, 0.01) | 0.812 | |
Comorbidities | −0.07 (−0.21, 0.06) | 0.272 | |
SO2 (%) | 25OHD (ng/mL) (log) | 0.97 (−0.66, 2.60) | 0.240 |
Sex (female) | −2.38 (−5.37, 0.61) | 0.116 | |
Age (years) | 0.02 (−0.09, 0.13) | 0.713 | |
Comorbidities | −1.08 (−2.48, 0.31) | 0.126 | |
PaO2 (mmHg) | 25OHD (ng/mL) (log) | 5.18 (0.83, 9.52) | 0.021 |
Sex (female) | −10.3 (−18.2, −2.3) | 0.012 | |
Age (years) | −0.03 (−0.33, 0.27) | 0.823 | |
Comorbidities | −1.37 (−5.06, 2.32) | 0.459 |
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Sulli, A.; Gotelli, E.; Casabella, A.; Paolino, S.; Pizzorni, C.; Alessandri, E.; Grosso, M.; Ferone, D.; Smith, V.; Cutolo, M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients 2021, 13, 717. https://doi.org/10.3390/nu13030717
Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021; 13(3):717. https://doi.org/10.3390/nu13030717
Chicago/Turabian StyleSulli, Alberto, Emanuele Gotelli, Andrea Casabella, Sabrina Paolino, Carmen Pizzorni, Elisa Alessandri, Marco Grosso, Diego Ferone, Vanessa Smith, and Maurizio Cutolo. 2021. "Vitamin D and Lung Outcomes in Elderly COVID-19 Patients" Nutrients 13, no. 3: 717. https://doi.org/10.3390/nu13030717
APA StyleSulli, A., Gotelli, E., Casabella, A., Paolino, S., Pizzorni, C., Alessandri, E., Grosso, M., Ferone, D., Smith, V., & Cutolo, M. (2021). Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients, 13(3), 717. https://doi.org/10.3390/nu13030717