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Review

Efficacy of Edible Bird’s Nest on Cognitive Functions in Experimental Animal Models: A Systematic Review

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Laboratory of Natural Medicines and Products, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
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Department of Pharmacology, Faculty of Pharmacy, Sana’a University, Mazbah District, Sana’a 1247, Yemen
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Department of Community Health, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
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UZMA Clinic, Kelana Mall, SS6/12 Road, SS 6, Petaling Jaya 47301, Selangor, Malaysia
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Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Giovambattista Desideri
Nutrients 2021, 13(3), 1028; https://doi.org/10.3390/nu13031028
Received: 27 January 2021 / Revised: 21 February 2021 / Accepted: 22 February 2021 / Published: 23 March 2021
(This article belongs to the Section Clinical Nutrition)
Edible bird’s nest (EBN) is constructed from saliva of swiftlets birds and consumed largely by Southeast and East Asians for its nutritional value and anti-aging properties. Although the neuroprotection of EBN in animals has been reported, there has not been yet systemically summarized. Thus, this review systemically outlined the evidence of the neuroprotective activity of EBN in modulating the cognitive functions of either healthy or with induced-cognitive dysfunction animals as compared to placebos. The related records from 2010 to 2020 were retrieved from PubMed, Scopus, Web of Science and ScienceDirect using pre-specified keywords. The relevant records to the effect of EBN on cognition were selected according to the eligibility criteria and these studies underwent appraisal for the risk of bias. EBN improved the cognitive functions of induced-cognitive dysfunction and enhanced the cognitive performance of healthy animals as well as attenuated the neuroinflammations and neuro-oxidative stress in the hippocampus of these animals. Malaysian EBN could improve the cognitive functions of experimental animals as a treatment in induced cognitive dysfunction, a nutritional cognitive-enhancing agent in offspring and a prophylactic conservative effect on cognition against exposure to subsequent noxious cerebral accidents in a dose-depended manner through attenuating neuroinflammation and neuro-oxidative stress. This systemic review did not proceed meta-analysis. View Full-Text
Keywords: cognition; neurodegeneration; neuroprotection; edible birds’ nest; systematic review cognition; neurodegeneration; neuroprotection; edible birds’ nest; systematic review
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MDPI and ACS Style

Ismail, M.; Alsalahi, A.; Aljaberi, M.A.; Ibrahim, R.M.; Bakar, F.A.; Ideris, A. Efficacy of Edible Bird’s Nest on Cognitive Functions in Experimental Animal Models: A Systematic Review. Nutrients 2021, 13, 1028. https://doi.org/10.3390/nu13031028

AMA Style

Ismail M, Alsalahi A, Aljaberi MA, Ibrahim RM, Bakar FA, Ideris A. Efficacy of Edible Bird’s Nest on Cognitive Functions in Experimental Animal Models: A Systematic Review. Nutrients. 2021; 13(3):1028. https://doi.org/10.3390/nu13031028

Chicago/Turabian Style

Ismail, Maznah, Abdulsamad Alsalahi, Musheer A. Aljaberi, Ramlah M. Ibrahim, Faizah A. Bakar, and Aini Ideris. 2021. "Efficacy of Edible Bird’s Nest on Cognitive Functions in Experimental Animal Models: A Systematic Review" Nutrients 13, no. 3: 1028. https://doi.org/10.3390/nu13031028

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