Next Article in Journal
Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies
Previous Article in Journal
Dairy Consumption and Incidence of Breast Cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) Project
 
 
Article

Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation

Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon 34134, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Ruggiero Francavilla
Nutrients 2021, 13(2), 688; https://doi.org/10.3390/nu13020688
Received: 18 January 2021 / Revised: 14 February 2021 / Accepted: 18 February 2021 / Published: 21 February 2021
(This article belongs to the Section Clinical Nutrition)
The link between autism spectrum disorder (ASD) and the gut microbiome has received much attention, with special focus on gut–brain-axis immunological imbalances. Gastrointestinal problems are one of the major symptoms of ASD and are thought to be related to immune dysregulation. Therefore, in silico analysis was performed on mined data from 36 individuals with ASD and 21 control subjects, with an emphasis on lipid A endotoxin-producing bacteria and their lipopolysaccharide (LPS) metabolic pathways. Analysis of enzyme distribution among the 15 most abundant genera in both groups revealed that almost all these genera utilized five early-stage enzymes responsible for catalyzing the nine conserved lipid A synthesis steps. However, Haemophilus and Escherichia, which were significantly more abundant in individuals with ASD than in the control subjects, possess a complete set of essential lipid A synthesis enzymes. Furthermore, the 10 genera with the greatest increase in individuals with ASD showed high potential for producing late-stage lipid A products. Collectively, these results suggested that the synthesis rate of immunogenic LPS end products is likely to increase in individuals with ASD, which may be related to their gastrointestinal symptoms and elevated inflammatory conditions. View Full-Text
Keywords: autism spectrum disorder; gut microbiome; Gram-negative bacteria; LPS biosynthesis; in silico analysis autism spectrum disorder; gut microbiome; Gram-negative bacteria; LPS biosynthesis; in silico analysis
Show Figures

Graphical abstract

MDPI and ACS Style

Maigoro, A.Y.; Lee, S. Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation. Nutrients 2021, 13, 688. https://doi.org/10.3390/nu13020688

AMA Style

Maigoro AY, Lee S. Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation. Nutrients. 2021; 13(2):688. https://doi.org/10.3390/nu13020688

Chicago/Turabian Style

Maigoro, Abdulkadir Yusif, and Soojin Lee. 2021. "Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation" Nutrients 13, no. 2: 688. https://doi.org/10.3390/nu13020688

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop