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Open AccessArticle

Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?

1
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany
2
Eating Disorder Treatment and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany
3
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany
4
Institute for Clinical Chemistry and Pathobiochemistry, Otto-Von-Guericke University Magdeburg, 39120 Magdeburg, Germany
5
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Ricarda Schmidt
Nutrients 2021, 13(2), 432; https://doi.org/10.3390/nu13020432
Received: 30 December 2020 / Revised: 22 January 2021 / Accepted: 25 January 2021 / Published: 29 January 2021
(This article belongs to the Special Issue Eating and Feeding Disorders with Restrictive Food Intake)
Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in the regulation of food intake and body weight, has been implicated in the development and maintenance of Anorexia nervosa (AN). The majority of previous studies reported lower BDNF levels in acutely underweight AN patients (acAN) and increasing levels after weight rehabilitation. Here, we investigated serum BDNF concentrations in the largest known AN sample to date, both before and after weight restoration therapy. Serum BDNF was measured in 259 female volunteers: 77 in-patient acAN participants of the restrictive type (47 reassessed after short-term weight rehabilitation), 62 individuals long-term recovered from AN, and 120 healthy controls. We validated our findings in a post-hoc mega-analysis in which we reanalyzed combined data from the current sample and those from our previous study on BDNF in AN (combined sample: 389 participants). All analyses carefully accounted for known determinants of BDNF (age, sex, storage time of blood samples). We further assessed relationships with relevant clinical variables (body-mass-index, physical activity, symptoms). Contrary to our hypotheses, we found zero significant differences in either cross-sectional or longitudinal comparisons and no significant relationships with clinical variables. Together, our study suggests that BDNF may not be a reliable state- or trait-marker in AN after all. View Full-Text
Keywords: brain-derived neurotrophic factor; BDNF; eating disorders; anorexia nervosa; food intake regulation; restrictive eating; endocrinology; neuroendocrinology; biomarkers; neuromarkers brain-derived neurotrophic factor; BDNF; eating disorders; anorexia nervosa; food intake regulation; restrictive eating; endocrinology; neuroendocrinology; biomarkers; neuromarkers
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MDPI and ACS Style

Steinhäuser, J.L.; King, J.A.; Tam, F.I.; Seidel, M.; Biemann, R.; Wronski, M.-L.; Geisler, D.; Roessner, V.; Ehrlich, S. Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa? Nutrients 2021, 13, 432. https://doi.org/10.3390/nu13020432

AMA Style

Steinhäuser JL, King JA, Tam FI, Seidel M, Biemann R, Wronski M-L, Geisler D, Roessner V, Ehrlich S. Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa? Nutrients. 2021; 13(2):432. https://doi.org/10.3390/nu13020432

Chicago/Turabian Style

Steinhäuser, Jonas L.; King, Joseph A.; Tam, Friederike I.; Seidel, Maria; Biemann, Ronald; Wronski, Marie-Louis; Geisler, Daniel; Roessner, Veit; Ehrlich, Stefan. 2021. "Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?" Nutrients 13, no. 2: 432. https://doi.org/10.3390/nu13020432

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