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Nutrients
Volume 13
Issue 2
10.3390/nu13020289
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Article

Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention

by
Amelia Marti
1,2,3,*,†,
Isabel Martínez
1,†,
Ana Ojeda-Rodríguez
1,2 and
María Cristina Azcona-Sanjulian
2,4
1
Department of Nutrition, Food Sciences and Physiology, University of Navarra, C/Irunlarrea, 31008 Pamplona, Spain
2
IdiSNA, Instituto de Investigación Sanitaria de Navarra, C/Irunlarrea, 3, 31008 Pamplona, Spain
3
Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Av. Monforte de Lemos, 3–5, 28029 Madrid, Spain
4
Paediatric Endocrinology Unit, Department of Paediatrics, Clínica Universidad de Navarra, Av. Pío XII, 36, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2021, 13(2), 289; https://doi.org/10.3390/nu13020289
Submission received: 22 December 2020 / Revised: 14 January 2021 / Accepted: 16 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue The Role of Diet and Nutrition in Preventing Abdominal Obesity)
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Abstract

Background: Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies are available on lifestyle intervention programs. We investigated the association of both LBP and chemerin plasma levels with metabolic syndrome (MetS) outcomes in a lifestyle intervention in children and adolescents with abdominal obesity Methods: Twenty-nine patients enrolled in a randomized controlled trial were selected. The lifestyle intervention with a 2-month intensive phase and a subsequent 10-month follow-up consisted of a moderate calorie-restricted diet, recommendations to increase physical activity levels, and nutritional education. Results: Weight loss was accompanied by a significant reduction in MetS prevalence (−43%; p = 0.009). Chemerin (p = 0.029) and LBP (p = 0.033) plasma levels were significantly reduced at 2 months and 12 months, respectively. At the end of intervention, MetS components were associated with both LBP (p = 0.017) and chemerin (p < 0.001) plasma levels. Conclusions: We describe for the first time a reduction in both LBP and chemerin plasma levels and its association with MetS risk factors after a lifestyle intervention program in children and adolescents with abdominal obesity. Therefore, LBP and chemerin plasma levels could be used as biomarkers for the progression of cardiovascular risk in pediatric populations.
Keywords: lifestyle intervention; obese children; chemerin; metabolic syndrome; lipopolysaccharide binding protein lifestyle intervention; obese children; chemerin; metabolic syndrome; lipopolysaccharide binding protein

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MDPI and ACS Style

Marti, A.; Martínez, I.; Ojeda-Rodríguez, A.; Azcona-Sanjulian, M.C. Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention. Nutrients 2021, 13, 289. https://doi.org/10.3390/nu13020289

AMA Style

Marti A, Martínez I, Ojeda-Rodríguez A, Azcona-Sanjulian MC. Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention. Nutrients. 2021; 13(2):289. https://doi.org/10.3390/nu13020289

Chicago/Turabian Style

Marti, Amelia, Isabel Martínez, Ana Ojeda-Rodríguez, and María Cristina Azcona-Sanjulian. 2021. "Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention" Nutrients 13, no. 2: 289. https://doi.org/10.3390/nu13020289

APA Style

Marti, A., Martínez, I., Ojeda-Rodríguez, A., & Azcona-Sanjulian, M. C. (2021). Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention. Nutrients, 13(2), 289. https://doi.org/10.3390/nu13020289

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