Next Article in Journal
Consumption of Oleic Acid on the Preservation of Cognitive Functions in Japanese Elderly Individuals
Next Article in Special Issue
Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review
Previous Article in Journal
Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention
Previous Article in Special Issue
Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 13
Issue 2
10.3390/nu13020288
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers

by
Silvie R. Ruigrok
1,
Maralinde R. Abbink
1,
Jorine Geertsema
1,
Jesse E. Kuindersma
1,
Nina Stöberl
1,
Eline M. van der Beek
2,
Paul J. Lucassen
1,
Lidewij Schipper
3 and
Aniko Korosi
1,*
1
Brain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands
2
Department of Pediatrics, University Medical Centre Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
3
Danone Nutricia Research, 3584 CT Utrecht, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(2), 288; https://doi.org/10.3390/nu13020288
Submission received: 11 December 2020 / Revised: 15 January 2021 / Accepted: 17 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue Nutrition and CNS: In Health and Disease)
Browse Figures
Review Reports Versions Notes

Abstract

Early-life stress (ES) exposure increases the risk of developing obesity. Breastfeeding can markedly decrease this risk, and it is thought that the physical properties of the lipid droplets in human milk contribute to this benefit. A concept infant milk formula (IMF) has been developed that mimics these physical properties of human milk (Nuturis®, N-IMF). Previously, we have shown that N-IMF reduces, while ES increases, western-style diet (WSD)-induced fat accumulation in mice. Peripheral and central inflammation are considered to be important for obesity development. We therefore set out to test the effects of ES, Nuturis® and WSD on adipose tissue inflammatory gene expression and microglia in the arcuate nucleus of the hypothalamus. ES was induced in mice by limiting the nesting and bedding material from postnatal day (P) 2 to P9. Mice were fed a standard IMF (S-IMF) or N-IMF from P16 to P42, followed by a standard diet (STD) or WSD until P230. ES modulated adipose tissue inflammatory gene expression early in life, while N-IMF had lasting effects into adulthood. Centrally, ES led to a higher microglia density and more amoeboid microglia at P9. In adulthood, WSD increased the number of amoeboid microglia, and while ES exposure increased microglia coverage, Nuturis® reduced the numbers of amoeboid microglia upon the WSD challenge. These results highlight the impact of the early environment on central and peripheral inflammatory profiles, which may be key in the vulnerability to develop metabolic derangements later in life.
Keywords: early-life stress; arcuate nucleus of the hypothalamus; western-style diet; adipose tissue; neuroinflammation; microglia early-life stress; arcuate nucleus of the hypothalamus; western-style diet; adipose tissue; neuroinflammation; microglia

Share and Cite

MDPI and ACS Style

Ruigrok, S.R.; Abbink, M.R.; Geertsema, J.; Kuindersma, J.E.; Stöberl, N.; van der Beek, E.M.; Lucassen, P.J.; Schipper, L.; Korosi, A. Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers. Nutrients 2021, 13, 288. https://doi.org/10.3390/nu13020288

AMA Style

Ruigrok SR, Abbink MR, Geertsema J, Kuindersma JE, Stöberl N, van der Beek EM, Lucassen PJ, Schipper L, Korosi A. Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers. Nutrients. 2021; 13(2):288. https://doi.org/10.3390/nu13020288

Chicago/Turabian Style

Ruigrok, Silvie R., Maralinde R. Abbink, Jorine Geertsema, Jesse E. Kuindersma, Nina Stöberl, Eline M. van der Beek, Paul J. Lucassen, Lidewij Schipper, and Aniko Korosi. 2021. "Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers" Nutrients 13, no. 2: 288. https://doi.org/10.3390/nu13020288

APA Style

Ruigrok, S. R., Abbink, M. R., Geertsema, J., Kuindersma, J. E., Stöberl, N., van der Beek, E. M., Lucassen, P. J., Schipper, L., & Korosi, A. (2021). Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers. Nutrients, 13(2), 288. https://doi.org/10.3390/nu13020288

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop