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Article

Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study

1
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
2
Department of Medicine, VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yoshitaka Hashimoto
Nutrients 2021, 13(11), 3965; https://doi.org/10.3390/nu13113965
Received: 19 October 2021 / Revised: 29 October 2021 / Accepted: 1 November 2021 / Published: 6 November 2021
(This article belongs to the Section Nutrition and Metabolism)
Grapes provide a rich source of polyphenols and fibers. This study aimed to evaluate the effect of the daily consumption of 46 g of whole grape powder, providing the equivalent of two servings of California table grapes, on the gut microbiome and cholesterol/bile acid metabolism in healthy adults. This study included a 4-week standardization to a low-polyphenol diet, followed by 4 weeks of 46 g of grape powder consumption while continuing the low-polyphenol diet. Compared to the baseline, 4 weeks of grape powder consumption significantly increased the alpha diversity index of the gut microbiome. There was a trend of increasing Verrucomicrobia (p = 0.052) at the phylum level, and a significant increase in Akkermansia was noted. In addition, there was an increase in Flavonifractor and Lachnospiraceae_UCG-010, but a decrease in Bifidobacterium and Dialister at the genus level. Grape powder consumption significantly decreased the total cholesterol by 6.1% and HDL cholesterol by 7.6%. There was also a trend of decreasing LDL cholesterol by 5.9%, and decreasing total bile acid by 40.9%. Blood triglyceride levels and body composition were not changed by grape powder consumption. In conclusion, grape powder consumption significantly modified the gut microbiome and cholesterol/bile acid metabolism. View Full-Text
Keywords: grape powder; gut microbiome; cholesterol; bile acids; healthy adults grape powder; gut microbiome; cholesterol; bile acids; healthy adults
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MDPI and ACS Style

Yang, J.; Kurnia, P.; Henning, S.M.; Lee, R.; Huang, J.; Garcia, M.C.; Surampudi, V.; Heber, D.; Li, Z. Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study. Nutrients 2021, 13, 3965. https://doi.org/10.3390/nu13113965

AMA Style

Yang J, Kurnia P, Henning SM, Lee R, Huang J, Garcia MC, Surampudi V, Heber D, Li Z. Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study. Nutrients. 2021; 13(11):3965. https://doi.org/10.3390/nu13113965

Chicago/Turabian Style

Yang, Jieping, Patrick Kurnia, Susanne M. Henning, Rupo Lee, Jianjun Huang, Michael C. Garcia, Vijaya Surampudi, David Heber, and Zhaoping Li. 2021. "Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study" Nutrients 13, no. 11: 3965. https://doi.org/10.3390/nu13113965

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