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Article

Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus

1
Faculty of Pharmacy, Saint Petersburg State Chemical Pharmaceutical University, 14, Prof. Popov Str., 197376 Saint-Petersburg, Russia
2
K.A. Tymyryazev Institute of Plant Physiology, Russian Academy of Sciences, 35, ul. Botanicheskaya, 127276 Moscow, Russia
3
Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, 119234 Moscow, Russia
4
Institute of Natural Sciences and Mathematics, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620026 Ekaterinburg, Russia
*
Authors to whom correspondence should be addressed.
Academic Editors: Iva Fernandes and Roberto Cangemi
Nutrients 2021, 13(11), 3811; https://doi.org/10.3390/nu13113811
Received: 9 July 2021 / Revised: 15 October 2021 / Accepted: 19 October 2021 / Published: 26 October 2021
(This article belongs to the Special Issue The Role of Secondary Plant Metabolites in Modern Human Nutrition)
In the present study, we explored the therapeutic potential of bioreactor-grown cell cultures of the medicinal plant species Dioscorea deltoidea, Tribulus terrestris and Panax japonicus to treat carbohydrate metabolism disorders (CMDs) in laboratory rats. In the adrenaline model of hyperglycemia, aqueous suspensions of cell biomass pre-administered at a dose of 100 mg dry biomass/kg significantly reduced glucose level in animal blood 1–2.5 h (D. deltoidea and T. terrestris) or 1 h (P. japonicus) after adrenaline hydrochloride administration. In a streptozotocin-induced model of type 2 diabetes mellitus, the cell biomass of D. deltoidea and T. terrestris acted towards normalization of carbohydrate and lipid metabolism, as evidenced by a significant reduction of daily diuresis (by 39–57%), blood-glucose level (by 46–51%), blood content in urine (by 78–80%) and total cholesterol (25–36%) compared to animals without treatment. Bioactive secondary metabolites identified in the cell cultures and potentially responsible for their actions were deltoside, 25(S)-protodioscin and protodioscin in D. deltoidea; furostanol-type steroidal glycosides and quinic acid derivatives in T. terrestris; and ginsenosides and malonyl-ginsenosides in P. japonicus. These results evidenced for high potential of bioreactor-grown cell suspensions of these species for prevention and treatment of CMD, which requires further investigation. View Full-Text
Keywords: adrenaline model; bioreactors; furostanol-type glycosides; hyperglycemia; plant cell culture; streptozotocin-induced type 2 diabetes mellitus adrenaline model; bioreactors; furostanol-type glycosides; hyperglycemia; plant cell culture; streptozotocin-induced type 2 diabetes mellitus
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MDPI and ACS Style

Povydysh, M.N.; Titova, M.V.; Ivanov, I.M.; Klushin, A.G.; Kochkin, D.V.; Galishev, B.A.; Popova, E.V.; Ivkin, D.Y.; Luzhanin, V.G.; Krasnova, M.V.; Demakova, N.V.; Nosov, A.M. Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus. Nutrients 2021, 13, 3811. https://doi.org/10.3390/nu13113811

AMA Style

Povydysh MN, Titova MV, Ivanov IM, Klushin AG, Kochkin DV, Galishev BA, Popova EV, Ivkin DY, Luzhanin VG, Krasnova MV, Demakova NV, Nosov AM. Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus. Nutrients. 2021; 13(11):3811. https://doi.org/10.3390/nu13113811

Chicago/Turabian Style

Povydysh, Maria N., Maria V. Titova, Igor M. Ivanov, Andrey G. Klushin, Dmitry V. Kochkin, Boris A. Galishev, Elena V. Popova, Dmitry Y. Ivkin, Vladimir G. Luzhanin, Marina V. Krasnova, Natalia V. Demakova, and Alexander M. Nosov. 2021. "Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus" Nutrients 13, no. 11: 3811. https://doi.org/10.3390/nu13113811

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