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Nutrients
Volume 13
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10.3390/nu13113779
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Article

Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life

by
Malin Barman
1,2,*,
Mia Stråvik
1,
Karin Broberg
2,3,
Anna Sandin
4,
Agnes E. Wold
5 and
Ann-Sofie Sandberg
1
1
Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden
2
Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden
3
Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 22363 Lund, Sweden
4
Pediatrics, Department of Clinical Sciences, Umeå University, 90187 Umeå, Sweden
5
Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(11), 3779; https://doi.org/10.3390/nu13113779
Submission received: 23 September 2021 / Revised: 19 October 2021 / Accepted: 20 October 2021 / Published: 25 October 2021
(This article belongs to the Special Issue The Relevance of Nutrition for Pediatric Allergy and Immunity)
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Abstract

Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric allergologist at 12 months of age. We found that higher proportions of n-6 PUFAs (including arachidonic acid) but lower proportions of n-3 PUFAs (including DPA) in the infant’s phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.
Keywords: diet; pregnancy; cord blood; fatty acids; n-3 PUFAs; n-6 PUFAs; arachidonic acid; phospholipids; atopic eczema; NICE birth cohort diet; pregnancy; cord blood; fatty acids; n-3 PUFAs; n-6 PUFAs; arachidonic acid; phospholipids; atopic eczema; NICE birth cohort

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MDPI and ACS Style

Barman, M.; Stråvik, M.; Broberg, K.; Sandin, A.; Wold, A.E.; Sandberg, A.-S. Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life. Nutrients 2021, 13, 3779. https://doi.org/10.3390/nu13113779

AMA Style

Barman M, Stråvik M, Broberg K, Sandin A, Wold AE, Sandberg A-S. Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life. Nutrients. 2021; 13(11):3779. https://doi.org/10.3390/nu13113779

Chicago/Turabian Style

Barman, Malin, Mia Stråvik, Karin Broberg, Anna Sandin, Agnes E. Wold, and Ann-Sofie Sandberg. 2021. "Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life" Nutrients 13, no. 11: 3779. https://doi.org/10.3390/nu13113779

APA Style

Barman, M., Stråvik, M., Broberg, K., Sandin, A., Wold, A. E., & Sandberg, A.-S. (2021). Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life. Nutrients, 13(11), 3779. https://doi.org/10.3390/nu13113779

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