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Systematic Review

Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80121 Naples, Italy
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
Oncology Unit, Hospital ‘Andrea Tortora’, ASL Salerno, 84016 Pagani, Italy
Associazione O.R.A., Somma Vesuviana, 80049 Naples, Italy
Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, 05100 Terni, Italy
Division of Urology, European Institute of Oncology IRCCS, 20141 Milan, Italy
Division of Laboratory Medicine, Civil Hospital ‘Maria SS. Addolorata’, ASL Salerno, 84025 Eboli, Italy
Urology Unit, Department of Woman Child and of General and Specialist Surgery, University of Campania “Luigi Vanvitelli”, Via S. Pansini 5, 80131 Naples, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Lynnette Ferguson
Nutrients 2021, 13(11), 3750;
Received: 5 October 2021 / Revised: 16 October 2021 / Accepted: 22 October 2021 / Published: 23 October 2021
(This article belongs to the Section Phytochemicals and Human Health)
Prostate and bladder cancer represent the two most frequently diagnosed genito-urinary malignancies. Diet has been implicated in both prostate and bladder cancer. Given their prolonged latency and high prevalence rates, both prostate and bladder cancer represent attractive candidates for dietary preventive measures, including the use of nutritional supplements. Flavonols, a class of flavonoids, are commonly found in fruit and vegetables and are known for their protective effect against diabetes and cardiovascular diseases. Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies. In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer. A total of 21, 15 and 7 pre-clinical articles on bladder or prostate cancer reporting on kaempferol, fisetin and myricetin, respectively, were found, while more limited evidence was available from animal models and epidemiological studies or clinical trials. In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions. View Full-Text
Keywords: fisetin; kaempferol; myricetin; prostate cancer; bladder cancer fisetin; kaempferol; myricetin; prostate cancer; bladder cancer
MDPI and ACS Style

Crocetto, F.; di Zazzo, E.; Buonerba, C.; Aveta, A.; Pandolfo, S.D.; Barone, B.; Trama, F.; Caputo, V.F.; Scafuri, L.; Ferro, M.; Cosimato, V.; Fusco, F.; Imbimbo, C.; Di Lorenzo, G. Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature. Nutrients 2021, 13, 3750.

AMA Style

Crocetto F, di Zazzo E, Buonerba C, Aveta A, Pandolfo SD, Barone B, Trama F, Caputo VF, Scafuri L, Ferro M, Cosimato V, Fusco F, Imbimbo C, Di Lorenzo G. Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature. Nutrients. 2021; 13(11):3750.

Chicago/Turabian Style

Crocetto, Felice, Erika di Zazzo, Carlo Buonerba, Achille Aveta, Savio D. Pandolfo, Biagio Barone, Francesco Trama, Vincenzo F. Caputo, Luca Scafuri, Matteo Ferro, Vincenzo Cosimato, Ferdinando Fusco, Ciro Imbimbo, and Giuseppe Di Lorenzo. 2021. "Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature" Nutrients 13, no. 11: 3750.

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