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Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model

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Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland
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Department of Fruit, Vegetable, and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, J. Chełmonskiego 37, 51-630 Wrocław, Poland
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Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland
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Department of Human Morphology and Embryology, Wroclaw Medical University, T. Chalubinskiego 6a, 50-368 Wroclaw, Poland
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Department of Pathology, Wrocław University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wrocław, Poland
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Bolestraszyce Arboretum and Institute of Physiography, Bolestraszyce 130, 37-722 Wyszatyce, Poland
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Institute of Physical Culture Sciences, Medical College, University of Rzeszów, Towarnickiego 3, 35-959 Rzeszów, Poland
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Author to whom correspondence should be addressed.
Academic Editor: LaVerne L. Brown
Nutrients 2021, 13(10), 3621; https://doi.org/10.3390/nu13103621
Received: 13 September 2021 / Revised: 4 October 2021 / Accepted: 14 October 2021 / Published: 16 October 2021
(This article belongs to the Special Issue Dietary Bioactives and Atherosclerotic Cardiovascular Disease)
Cornelian cherry (Cornus mas L.) fruits possess potential cardiovascular, lipid-lowering and hypoglycemic bioactivities. The aim of this study is to evaluate the influence of resin-purified cornelian cherry extract rich in iridoids and anthocyanins on several transcription factors, intima/media ratio in aorta and serum parameters, which determine or are valuable indicators of the adverse changes observed in the course of atherosclerosis, cardiovascular disease, and metabolic syndrome. For this purpose, male New Zealand rabbits were fed a diet enriched in 1% cholesterol for 60 days. Additionally, one group received 10 mg/kg b.w. of cornelian cherry extract and the second group 50 mg/kg b.w. of cornelian cherry extract. PPAR-α and PPAR-γ expression in the aorta, LXR-α expression in the liver; cholesterol, triglycerides, adipokines, apolipoproteins, glucose and insulin levels in serum; the intima and media diameter in the thoracic and abdominal aorta were determined. Administration of cornelian cherry extract resulted in an enhancement in the expression of all tested transcription factors, a decrease in triglycerides, leptin and resistin, and an increase in adiponectin levels. In addition, a significant reduction in the I/M ratio was observed for both the thoracic and abdominal aorta. The results we have obtained confirm the potential contribution of cornelian cherry extract to mitigation of the risk of developing and the intensity of symptoms of obesity-related cardiovascular diseases and metabolic disorders such as atherosclerosis or metabolic syndrome. View Full-Text
Keywords: cornelian cherry; iridoids; anthocyanins; transcription factors; adipokines; triglycerides; aorta; atherosclerosis; metabolic syndrome cornelian cherry; iridoids; anthocyanins; transcription factors; adipokines; triglycerides; aorta; atherosclerosis; metabolic syndrome
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MDPI and ACS Style

Danielewski, M.; Kucharska, A.Z.; Matuszewska, A.; Rapak, A.; Gomułkiewicz, A.; Dzimira, S.; Dzięgiel, P.; Nowak, B.; Trocha, M.; Magdalan, J.; Piórecki, N.; Szeląg, A.; Sozański, T. Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model. Nutrients 2021, 13, 3621. https://doi.org/10.3390/nu13103621

AMA Style

Danielewski M, Kucharska AZ, Matuszewska A, Rapak A, Gomułkiewicz A, Dzimira S, Dzięgiel P, Nowak B, Trocha M, Magdalan J, Piórecki N, Szeląg A, Sozański T. Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model. Nutrients. 2021; 13(10):3621. https://doi.org/10.3390/nu13103621

Chicago/Turabian Style

Danielewski, Maciej, Alicja Z. Kucharska, Agnieszka Matuszewska, Andrzej Rapak, Agnieszka Gomułkiewicz, Stanisław Dzimira, Piotr Dzięgiel, Beata Nowak, Małgorzata Trocha, Jan Magdalan, Narcyz Piórecki, Adam Szeląg, and Tomasz Sozański. 2021. "Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model" Nutrients 13, no. 10: 3621. https://doi.org/10.3390/nu13103621

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