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Article

Retrospective Evaluation on the Use of a New Polysaccharide Complex in Managing Paediatric Type 1 Diabetes with Metabolic Syndrome (MetS)

1
Department of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, 50139 Florence, Italy
2
Pediatric Diabetology Unit, Anna Meyer Children’s University Hospital, 50139 Florence, Italy
3
Department of Paediatrics, University of L’Aquila, 67100 L’Aquila, Italy
4
Department of Paediatrics, University of Chieti, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: J. Mark Brown
Nutrients 2021, 13(10), 3517; https://doi.org/10.3390/nu13103517
Received: 19 August 2021 / Revised: 26 September 2021 / Accepted: 1 October 2021 / Published: 7 October 2021
(This article belongs to the Section Nutrition and Diabetes)
Background: Children and adolescents affected by type 1 diabetes have an increased risk of being overweight or obese and of suffering from cardiometabolic symptoms. Aims: To retrospectively evaluate the effects of a new complex of polysaccharide macromolecules, Policaptil Gel Retard® (PGR), on auxological and metabolic parameters, glycaemic variability and control parameters in paediatric patients with type 1 diabetes and metabolic syndrome (MetS). Patients and Methods: Data for 27 paediatric patients with a diagnosis of type 1 diabetes in conjunction with obesity and MetS of at least 5 years’ standing were collected and retrospectively studied. Of these, 16 (median age 12.9, range 9.5–15.8 years) had been adjunctively treated with PGR and 11 (median age 12.6, range 9.4–15.6 years) had not been treated with PGR. Auxological, metabolic and glycaemic control and variability parameters and insulin dosing were compared after 6 months in the two groups. Results: PGR significantly reduced BMI standard deviation score (SDS) (p < 0.005), waist SDS (p < 0.005), HbA1c (p < 0.05) and daily mean insulin dose requirement (p < 0.005). A significant improvement was also observed in the metabolic and glycaemic variability parameters of mean daily blood glucose (BG) levels (p < 0.005), SD of daily BG levels (p < 0.0001), mean coefficient of variation (p < 0.05), LBGI (p < 0.0001), HBGI (p < 0.0001), J-index (p < 0.005), total cholesterol (p < 0.005), HDL-cholesterol (p < 0.005) and LDL-cholesterol (p < 0.005) and triglycerides (p < 0.05). Conclusions: PGR produces a good auxological and metabolic response in obese patients with MetS who are affected by type 1 diabetes. It led to a significant reduction in BMI SDS, waist SDS and an improvement in glucose control and variability as well as in other MetS parameters. The use of polysaccharide compounds, especially if associated with appropriate dietary changes, may help achieve treatment targets in type 1 diabetes and reduce the risk that patients develop metabolic syndrome. View Full-Text
Keywords: children; Policaptil Gel Retard®; type 1 diabetes; obesity; overweight; haemoglobin A1c; treatment; metabolic syndrome; MetS; glycaemic index; insulin dosing children; Policaptil Gel Retard®; type 1 diabetes; obesity; overweight; haemoglobin A1c; treatment; metabolic syndrome; MetS; glycaemic index; insulin dosing
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MDPI and ACS Style

Stagi, S.; Papacciuoli, V.; Ciofi, D.; Piccini, B.; Farello, G.; Toni, S.; Ferrari, M.; Chiarelli, F. Retrospective Evaluation on the Use of a New Polysaccharide Complex in Managing Paediatric Type 1 Diabetes with Metabolic Syndrome (MetS). Nutrients 2021, 13, 3517. https://doi.org/10.3390/nu13103517

AMA Style

Stagi S, Papacciuoli V, Ciofi D, Piccini B, Farello G, Toni S, Ferrari M, Chiarelli F. Retrospective Evaluation on the Use of a New Polysaccharide Complex in Managing Paediatric Type 1 Diabetes with Metabolic Syndrome (MetS). Nutrients. 2021; 13(10):3517. https://doi.org/10.3390/nu13103517

Chicago/Turabian Style

Stagi, Stefano, Valeria Papacciuoli, Daniele Ciofi, Barbara Piccini, Giovanni Farello, Sonia Toni, Marta Ferrari, and Francesco Chiarelli. 2021. "Retrospective Evaluation on the Use of a New Polysaccharide Complex in Managing Paediatric Type 1 Diabetes with Metabolic Syndrome (MetS)" Nutrients 13, no. 10: 3517. https://doi.org/10.3390/nu13103517

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