Growth, Tolerance, and Compliance of Infants Fed an Extensively Hydrolyzed Infant Formula with Added 2′-FL Fucosyllactose (2′-FL) Human Milk Oligosaccharide
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Methods
2.3. Statistical Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gender, n (%) | |
Male | 22 (61.1) |
Female | 14 (38.9) |
Is Participant Hispanic/Latino, n (%) | |
Hispanic or Latino | 3 (8.3) |
Not Hispanic or Latino | 33 (91.7) |
Mode of Delivery, n (%) | |
Vaginal | 24 (66.7) |
C-Section | 12 (33.3) |
Pre-study Feeding Regimen, n (%) | |
Alimentum without 2′-FL | 33 (91.7) |
Nutramigen without 2′-FL | 3 (8.3) |
Gestational Age: Weeks | |
Mean ± SEM | 38.6 ± 0.2 |
Age at SDAY 1: Days | |
Mean ± SEM | 33.2 ± 2.8 |
Birth Weight (g) | |
Mean ± SEM | 3262.5 ± 101.6 |
Visits | |||
---|---|---|---|
SDAY 1 | SDAY 30 | SDAY 60 | |
Mean ± SEM | −0.37 ± 0.20 | −0.24 ± 0.19 | −0.05 ± 0.17 |
Median | −0.24 | −0.12 | 0.04 |
Q1, Q3 | −0.75, 0.28 | −0.74, 0.59 | −0.54, 0.83 |
Std Dev | 1.18 | 1.11 | 1.02 |
Min, Max | −3.94, 1.62 | −3.55, 1.52 | −2.31, 2.04 |
n | 36 | 35 | 36 |
Clinical Symptoms | Prior to Being Placed on a Hypoallergenic Extensively Hydrolyzed Formula | At Study Initiation | At Study Visit 2 (Day 7), n (% of Subjects with the Symptom at Entry) | At Study Visit 4 (Day 60), n (% of Subjects with the Symptom at Entry) |
---|---|---|---|---|
Diarrhea | 9 | 2 | 1 (50%)—Same 1 (50%)—Resolved | 2 (100%)—Better |
Constipation | 18 | 6 | 4 (67%)—Better 1 (17%)—Resolved 1 (17%)—Worse | 1 (17%)—Same 3 (50%)—Better 2 (33%)—Resolved |
Blood in stool | 4 | 1 | 1 (100%)—Resolved | 1 (100%)—Resolved |
Vomiting | 11 | 4 | 1 (25%)—Better 3 (75%)—Resolved | 1 (25%)—Same 3 (75%)—Resolved |
Spit-up/Gagging/Reflux | 25 | 17 | 6 (35%)—Same 10 (59%)—Better 1 (6%)—Worse | 5 (29%)—Same 10 (59%)—Better 2 (12%)—Resolved |
Fussiness | 24 | 10 | 5 (50%)—Same 2 (20%)—Better 2 (20%)—Resolved 1 (10%)—Worse | 4 (40%)—Same 2 (20%)—Better 4 (40%)—Resolved |
Rash or Eczema | 9 | 7 | 2 (29%)—Same 4 (57%)—Better 1 (14%)—Resolved | 2 (29%)—Same 3 (43%)—Better 2 (29%)—Resolved |
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Ramirez-Farias, C.; Baggs, G.E.; Marriage, B.J. Growth, Tolerance, and Compliance of Infants Fed an Extensively Hydrolyzed Infant Formula with Added 2′-FL Fucosyllactose (2′-FL) Human Milk Oligosaccharide. Nutrients 2021, 13, 186. https://doi.org/10.3390/nu13010186
Ramirez-Farias C, Baggs GE, Marriage BJ. Growth, Tolerance, and Compliance of Infants Fed an Extensively Hydrolyzed Infant Formula with Added 2′-FL Fucosyllactose (2′-FL) Human Milk Oligosaccharide. Nutrients. 2021; 13(1):186. https://doi.org/10.3390/nu13010186
Chicago/Turabian StyleRamirez-Farias, Carlett, Geraldine E. Baggs, and Barbara J. Marriage. 2021. "Growth, Tolerance, and Compliance of Infants Fed an Extensively Hydrolyzed Infant Formula with Added 2′-FL Fucosyllactose (2′-FL) Human Milk Oligosaccharide" Nutrients 13, no. 1: 186. https://doi.org/10.3390/nu13010186