Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease

Choi, Ye Rin; Kim, Hyeong Seop; Yoon, Sang Jun; Lee, Na Young; Gupta, Haripriya; Raja, Ganesan; Gebru, Yoseph Asmelash; Youn, Gi Soo; Kim, Dong Joon; Ham, Young Lim; Suk, Ki Tae

doi:10.3390/nu13010185

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Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease

^1,†

^1,†,

Yoseph Asmelash Gebru

¹,

^2,* and

^1,*

Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea

Department of Nursing, Daewon University College, Jaecheon 27135, Korea

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Nutrients 2021, 13(1), 185; https://doi.org/10.3390/nu13010185

Received: 2 December 2020 / Revised: 2 January 2021 / Accepted: 7 January 2021 / Published: 9 January 2021

(This article belongs to the Section Nutritional Epidemiology)

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Abstract

Malnutrition and cognitive dysfunction are typical features of alcoholic liver disease (ALD) and are correlated with the development of complications. The aim of this study is to explore the effect of nutritional state and diet on cognitive function in ALD. A total of 43 patients with compensated alcoholic cirrhosis were enrolled, and a neuropsychological test was assessed according to body mass index (BMI, <22 and ≥22). In the ALD animal study, mice were divided into five groups (n = 9/group; normal liquid, 5% EtOH + regular liquid, 5% EtOH + high-carbohydrate liquid, 5% EtOH + high-fat liquid, and 5% EtOH + high-protein liquid diet) and fed the same calories for eight weeks. To assess cognitive function, we performed T-maze studies weekly before/after alcohol binging. In cognitive function (BMI < 22/≥22), language score of Korea mini-mental state (7.4 ± 1.4/7.9 ± 0.4), Boston naming (11.7 ± 2.7/13.0 ± 1.8), forward digit span (6.7 ± 1.8/7.5 ± 1.6), Korean color word stroop (24.2 ± 26.5/43.6 ± 32.4), and interference score (33.9 ± 31.9/52.3 ± 33.9) revealed significant differences. In the T-maze test, alcohol significantly delayed the time to reach food, and binge drinking provided a temporary recovery in cognition. The alcohol-induced delay was significantly reduced in the high-carbohydrate and high-fat diet groups. Synaptic function exhibited no changes in all groups. Cognitive dysfunction is affected by nutritional status and diet in ALD. View Full-Text

Keywords: alcoholic liver disease; cognitive function; calorie intake; nutrition; BMI

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Choi, Y.R.; Kim, H.S.; Yoon, S.J.; Lee, N.Y.; Gupta, H.; Raja, G.; Gebru, Y.A.; Youn, G.S.; Kim, D.J.; Ham, Y.L.; Suk, K.T. Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease. Nutrients 2021, 13, 185. https://doi.org/10.3390/nu13010185

AMA Style

Choi YR, Kim HS, Yoon SJ, Lee NY, Gupta H, Raja G, Gebru YA, Youn GS, Kim DJ, Ham YL, Suk KT. Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease. Nutrients. 2021; 13(1):185. https://doi.org/10.3390/nu13010185

Chicago/Turabian Style

Choi, Ye R., Hyeong S. Kim, Sang J. Yoon, Na Y. Lee, Haripriya Gupta, Ganesan Raja, Yoseph A. Gebru, Gi S. Youn, Dong J. Kim, Young L. Ham, and Ki T. Suk. 2021. "Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease" Nutrients 13, no. 1: 185. https://doi.org/10.3390/nu13010185

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Author Biographies

Ye Rin Choi

They are involved in master's degree programs at the Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, Republic of Korea. Their interest is microbiome and liver disease and nutrition.

Hyeong Seop Kim

Sang Jun Yoon

They are involved in doctoral's degree programs at the Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, Republic of Korea. Their interest is microbiome and liver disease and nutrition.

Na Young Lee

Haripriya Gupta

They are involved in Post-Doc degree programs at the Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, Republic of Korea. Their interest is microbiome and liver disease and nutrition.

Ganesan Raja

Yoseph Asmelash Gebru

Gi Soo Youn

Dong Joon Kim

He is a Professor at the Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, Republic of Korea. His interest is microbiome and liver disease and nutrition.

Young Lim Ham

She is a Professor at the Department of Nursing, Daewon University College, Jaecheon, Republic of Korea.

Ki Tae Suk

He is a Professor at thee Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, Republic of Korea. His interest is microbiome and liver disease and nutrition.

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Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease

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