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Article

Vitamin D and Immunological Patterns of Allergic Diseases in Children

1
Pediatric, Nephrology and Allergology Clinic, Military Institute of Medicine, 04-141 Warsaw, Poland
2
Laboratory of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), 04-141 Warsaw, Poland
3
Cell Cycle Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes 1, UMR 6290, CNRS, Rennes, France
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 177; https://doi.org/10.3390/nu13010177
Received: 24 November 2020 / Revised: 3 January 2021 / Accepted: 5 January 2021 / Published: 8 January 2021
Vitamin D, in addition to its superior role as a factor regulating calcium-phosphate metabolism, shows wide effects in other processes in the human body, including key functions of the immune system. This is due to the presence of vitamin D receptors in most cells of the human body. In our study, we aimed to assess whether there is a correlation between vitamin D content and the clinical course of allergic diseases as well as establish their immunological parameters in children. We found that vitamin D deficiency was significantly more frequent in the group of children with an allergic disease than in the control group (p = 0.007). Statistically significant higher vitamin D concentrations in blood were observed in the group of children with a mild course of the disease compared to children with a severe clinical course (p = 0.03). In the group of children with vitamin D deficiency, statistically significant lower percentages of NKT lymphocytes and T-regulatory lymphocytes were detected compared to the group of children without deficiency (respectively, p = 0.02 and p = 0.05), which highlights a potential weakness of the immune system in these patients. Furthermore, statistically higher levels of interleukin-22 were observed in the group of children with vitamin D deficiency (p = 0.01), suggesting a proinflammatory alert state. In conclusion, these results confirm the positive relationship between the optimal content of vitamin D and the lesser severity of allergic diseases in children, establishing weak points in the immune system caused by vitamin D deficiency in children. View Full-Text
Keywords: vitamin D; asthma; atopic dermatitis; regulatory T cells; children vitamin D; asthma; atopic dermatitis; regulatory T cells; children
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MDPI and ACS Style

Lipińska-Opałka, A.; Tomaszewska, A.; Kubiak, J.Z.; Kalicki, B. Vitamin D and Immunological Patterns of Allergic Diseases in Children. Nutrients 2021, 13, 177. https://doi.org/10.3390/nu13010177

AMA Style

Lipińska-Opałka A, Tomaszewska A, Kubiak JZ, Kalicki B. Vitamin D and Immunological Patterns of Allergic Diseases in Children. Nutrients. 2021; 13(1):177. https://doi.org/10.3390/nu13010177

Chicago/Turabian Style

Lipińska-Opałka, Agnieszka, Agata Tomaszewska, Jacek Z. Kubiak, and Bolesław Kalicki. 2021. "Vitamin D and Immunological Patterns of Allergic Diseases in Children" Nutrients 13, no. 1: 177. https://doi.org/10.3390/nu13010177

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