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Magnesium in Infectious Diseases in Older People

1
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90100 Palermo, Italy
2
Mexican Institute of Social Security IMSS, Biomedical Research Unit, Durango, ZC 34067, Mexico
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 180; https://doi.org/10.3390/nu13010180
Received: 16 December 2020 / Revised: 30 December 2020 / Accepted: 4 January 2021 / Published: 8 January 2021
(This article belongs to the Special Issue Magnesium and Microelements in Older Persons)
Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells. Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune cells involves Mg transport systems, such as the melastatin-like transient receptor potential 7 channel, the solute carrier family, and the magnesium transporter 1 (MAGT1). The functional importance of Mg transport in immunity was unknown until the description of the primary immunodeficiency XMEN (X-linked immunodeficiency with Mg defect, Epstein–Barr virus infection, and neoplasia) due to a genetic deficiency of MAGT1 characterized by chronic Epstein–Barr virus infection. This and other research reporting associations of Mg deficit with viral and bacterial infections indicate a possible role of Mg deficit in the recent coronavirus disease 2019 (COVID-19) and its complications. In this review, we will discuss the importance of Mg for the immune system and for infectious diseases, including the recent pandemic of COVID-19. View Full-Text
Keywords: magnesium; oxidative stress; inflammation; aging; infectious diseases; vitamin D; COVID-19 magnesium; oxidative stress; inflammation; aging; infectious diseases; vitamin D; COVID-19
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MDPI and ACS Style

Dominguez, L.J.; Veronese, N.; Guerrero-Romero, F.; Barbagallo, M. Magnesium in Infectious Diseases in Older People. Nutrients 2021, 13, 180. https://doi.org/10.3390/nu13010180

AMA Style

Dominguez LJ, Veronese N, Guerrero-Romero F, Barbagallo M. Magnesium in Infectious Diseases in Older People. Nutrients. 2021; 13(1):180. https://doi.org/10.3390/nu13010180

Chicago/Turabian Style

Dominguez, Ligia J., Nicola Veronese, Fernando Guerrero-Romero, and Mario Barbagallo. 2021. "Magnesium in Infectious Diseases in Older People" Nutrients 13, no. 1: 180. https://doi.org/10.3390/nu13010180

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