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Nutrition, Bioenergetics, and Metabolic Syndrome

Muscle Research and Mitochondrial Function Laboratory, CELLEX-IDIBAPS, Internal Medicine Department, Faculty of Medicine, University of Barcelona, Hospital Clinic of Barcelona, 08036 Barcelona, Spain
CIBERER—Centre for Biomedical Research Network in Rare Diseases, 28029 Madrid, Spain
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2785;
Received: 6 August 2020 / Revised: 5 September 2020 / Accepted: 7 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Dietary Intakes and Metabolic Disorders)
According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world’s population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden. View Full-Text
Keywords: mitochondria; metabolic syndrome; mitochondrial dysfunction; balanced diet; nutrients; lifestyle mitochondria; metabolic syndrome; mitochondrial dysfunction; balanced diet; nutrients; lifestyle
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MDPI and ACS Style

García-García, F.J.; Monistrol-Mula, A.; Cardellach, F.; Garrabou, G. Nutrition, Bioenergetics, and Metabolic Syndrome. Nutrients 2020, 12, 2785.

AMA Style

García-García FJ, Monistrol-Mula A, Cardellach F, Garrabou G. Nutrition, Bioenergetics, and Metabolic Syndrome. Nutrients. 2020; 12(9):2785.

Chicago/Turabian Style

García-García, Francesc J., Anna Monistrol-Mula, Francesc Cardellach, and Glòria Garrabou. 2020. "Nutrition, Bioenergetics, and Metabolic Syndrome" Nutrients 12, no. 9: 2785.

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