ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer
Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, Italy
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Nutrients 2020, 12(9), 2751; https://doi.org/10.3390/nu12092751
Received: 5 August 2020 / Revised: 1 September 2020 / Accepted: 7 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Nutraceuticals and Human Health)
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food–related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.
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Keywords:
obesity; ω-3PUFAs; ω-6PUFAs; endocannabinoids; CRC; fatty acids
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MDPI and ACS Style
D’Angelo, S.; Motti, M.L.; Meccariello, R. ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer. Nutrients 2020, 12, 2751. https://doi.org/10.3390/nu12092751
AMA Style
D’Angelo S, Motti ML, Meccariello R. ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer. Nutrients. 2020; 12(9):2751. https://doi.org/10.3390/nu12092751
Chicago/Turabian StyleD’Angelo, Stefania; Motti, Maria L.; Meccariello, Rosaria. 2020. "ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer" Nutrients 12, no. 9: 2751. https://doi.org/10.3390/nu12092751
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