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Open AccessArticle

Risk Reduction for End-Stage Renal Disease by Dietary Guidance Using the Gustatory Threshold Test for Salty Taste

1
Department of Nephrology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
2
Department of Nephrology, Sasebo City General Hospital, 9-3 Hirase-cho, Sasebo, Nagasaki 857-8511, Japan
3
Department of Nutritional Management, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
4
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2703; https://doi.org/10.3390/nu12092703
Received: 24 June 2020 / Revised: 22 August 2020 / Accepted: 30 August 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Dietary Interventions in Chronic Kidney Disease)
Educational hospitalization of patients with chronic kidney disease (CKD) may slow the progression of renal dysfunction. However, the educational aspect that is more effective has not been identified to date. In this study, patients with CKD were evaluated for gustatory threshold for salty taste and received augmented salt reduction guidance under educational hospitalization at Nagasaki University Hospital from October 2016. In total, 277 eligible patients were enrolled and hospitalized from 2012 to 2019 (mean age of 69.2 years; men comprised 62.1%). We compared 141 patients (Group A) who were educated in the hospital after October 2016 and 136 patients (Group B) who received standard education in the hospital before October 2016. The changes in the estimated glomerular filtration rate (ΔeGFR) after hospitalization and dialysis induction rate within one year after hospitalization were evaluated. The ΔeGFR was significantly improved in Group A compared to Group B (A: 1.05 mL/min/1.73 m2/month, B: 0.55 mL/min/1.73 m2/month; p = 0.02). The dialysis induction rate was significantly lower in Group A than in Group B (A: 8.5%, B: 15.5%; p = 0.001). These trends were also observed by multivariate analyses. In conclusion, educational hospitalization with enhanced salt reduction guidance may reduce the risk of end-stage renal disease. View Full-Text
Keywords: chronic kidney disease; educational hospitalization; gustatory threshold test; salty taste chronic kidney disease; educational hospitalization; gustatory threshold test; salty taste
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Ota, Y.; Kitamura, M.; Tsuji, K.; Torigoe, K.; Yamashita, A.; Abe, S.; Muta, K.; Uramatsu, T.; Obata, Y.; Furutani, J.; Takashima, M.; Mukae, H.; Nishino, T. Risk Reduction for End-Stage Renal Disease by Dietary Guidance Using the Gustatory Threshold Test for Salty Taste. Nutrients 2020, 12, 2703.

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