Next Article in Journal
Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease
Next Article in Special Issue
Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Infant’s Anthropometry at Birth
Previous Article in Journal
The Effect of Coffee and Caffeine Consumption on Patients with Multiple Sclerosis-Related Fatigue
Previous Article in Special Issue
Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women
Article

Periconceptional Folic Acid Supplementation and the Risk of Spontaneous Abortion among Women Who Prepared to Conceive: Impact of Supplementation Initiation Timing

1
NHC Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 200237, China
2
NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, China
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2264; https://doi.org/10.3390/nu12082264
Received: 2 July 2020 / Revised: 18 July 2020 / Accepted: 26 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Effect of Folate Intake on Health Outcomes in Pregnancy)
It is unclear whether periconceptional folic acid (FA) supplementation decreases the risk of spontaneous abortion (SA). The impact of supplementation initiation timing has not been ascertained. This cohort study aimed to investigate the association between maternal periconceptional FA supplementation and risk of SA, with due consideration of the supplementation initiation timing. Through the National Free Pre-conception Health Examination Project (NFPHEP), we identified 65,643 pregnancies on FA supplementation in Chongqing, China between 2010 and 2015. After adjusting for covariates, maternal periconceptional FA supplementation was associated with a lower risk of SA (adjusted risk ratio [aRR]: 0.52; 95% confidence interval [CI]: 0.48–0.56). Pregnant women with FA supplementation initiated at least 3 months before conception had a 10% lower risk of SA (aRR: 0.46; 95% CI: 0.42–0.50) than those with FA supplementation initiated 1–2 months before conception (aRR: 0.56; 95% CI: 0.50–0.62) or after conception (aRR: 0.56; 95% CI: 0.51–0.61). These associations might not thoroughly account for FA supplementation, and to some extent our findings confirm the role of the utilization of healthcare in preventing SAs. Women who initiated healthcare, including taking FA earlier during the periconceptional period, could have a lower risk of SA. View Full-Text
Keywords: folic acid; supplementation; periconceptional; initial time; spontaneous abortion folic acid; supplementation; periconceptional; initial time; spontaneous abortion
Show Figures

Figure 1

MDPI and ACS Style

Mao, Y.-Y.; Yang, L.; Li, M.; Liu, J.; Zhu, Q.-X.; He, Y.; Zhou, W.-J. Periconceptional Folic Acid Supplementation and the Risk of Spontaneous Abortion among Women Who Prepared to Conceive: Impact of Supplementation Initiation Timing. Nutrients 2020, 12, 2264. https://doi.org/10.3390/nu12082264

AMA Style

Mao Y-Y, Yang L, Li M, Liu J, Zhu Q-X, He Y, Zhou W-J. Periconceptional Folic Acid Supplementation and the Risk of Spontaneous Abortion among Women Who Prepared to Conceive: Impact of Supplementation Initiation Timing. Nutrients. 2020; 12(8):2264. https://doi.org/10.3390/nu12082264

Chicago/Turabian Style

Mao, Yan-Yan, Liu Yang, Min Li, Jun Liu, Qian-Xi Zhu, Yang He, and Wei-Jin Zhou. 2020. "Periconceptional Folic Acid Supplementation and the Risk of Spontaneous Abortion among Women Who Prepared to Conceive: Impact of Supplementation Initiation Timing" Nutrients 12, no. 8: 2264. https://doi.org/10.3390/nu12082264

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop