Next Article in Journal
Are the Results of a Combined Behavioural and Surgical Treatment of Morbid Obesity Satisfactory and Predictable?
Previous Article in Journal
Association between Egg Consumption and Cholesterol Concentration: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Previous Article in Special Issue
Chenopodium Quinoa and Salvia Hispanica Provide Immunonutritional Agonists to Ameliorate Hepatocarcinoma Severity under a High-Fat Diet
Open AccessArticle

Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm Infants

1
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, 40530 Gothenburg, Sweden
2
Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41686 Gothenburg, Sweden
3
Institute of Bioscience, Sahlgrenska Academy at University of Gothenburg, 40530 Gothenburg, Sweden
4
Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
5
Department of Pathology, Region Västra Götaland, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden
6
Department of Neonatology, Region Västra Götaland, the Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden
7
Department of Clinical Science and Education, Stockholm South General Hospital, Karolinska Institutet, 11883 Solna, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1996; https://doi.org/10.3390/nu12071996
Received: 25 May 2020 / Revised: 18 June 2020 / Accepted: 4 July 2020 / Published: 5 July 2020
(This article belongs to the Special Issue Lipid Metabolism in Inflammation and Immune Function)
Fetal and early postnatal inflammation have been associated with increased morbidity in extremely preterm infants. This study aimed to demonstrate if postpartum levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) were associated with early inflammation. In a cohort of 90 extremely preterm infants, DHA and AA in cord blood, on the first postnatal day and on postnatal day 7 were examined in relation to early systemic inflammation, defined as elevated C-reactive protein (CRP) and/or interleukin-6 (IL-6) within 72 h from birth, with or without positive blood culture. Median serum level of DHA was 0.5 mol% (95% CI (confidence interval) 0.2–0.9, P = 0.006) lower than the first postnatal day in infants with early systemic inflammation, compared to infants without signs of inflammation, whereas levels of AA were not statistically different between infants with and without signs of inflammation. In cord blood, lower serum levels of both DHA (correlation coefficient −0.40; P = 0.010) and AA (correlation coefficient −0.54; p < 0.001) correlated with higher levels of IL-6. Levels of DHA or AA did not differ between infants with and without histological signs of chorioamnionitis or fetal inflammation. In conclusion, serum levels of DHA at birth were associated with the inflammatory response during the early postnatal period in extremely preterm infants. View Full-Text
Keywords: inflammation; preterm infant; polyunsaturated fatty acid; interleukin-6 inflammation; preterm infant; polyunsaturated fatty acid; interleukin-6
Show Figures

Figure 1

MDPI and ACS Style

Hellström, A.; Hellström, W.; Hellgren, G.; E. H. Smith, L.; Puttonen, H.; Fyhr, I.-M.; Sävman, K.; Nilsson, A.K.; Klevebro, S. Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm Infants. Nutrients 2020, 12, 1996.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop