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Potential of Skin Microbiome, Pro- and/or Pre-Biotics to Affect Local Cutaneous Responses to UV Exposure

1
Center for Medical Research, Medical University of Graz, 8010 Graz, Austria
2
Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, 8010 Graz, Austria
3
Department of Medicine, Unit of Rheumatology, Karolinska Institutet, 171 77 Solna, Sweden
4
Department of Dermatology, Besançon University Hospital, 25000 Besancon, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1795; https://doi.org/10.3390/nu12061795
Received: 4 June 2020 / Revised: 14 June 2020 / Accepted: 15 June 2020 / Published: 17 June 2020
(This article belongs to the Special Issue Role of Prebiotics and Probiotics in Health and Disease)
The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, and immune modulation. Phototherapy on the other hand is widely used to treat inflammatory skin diseases such as psoriasis, atopic dermatitis, polymorphic light eruption and graft-versus-host disease (GvHD), as well as neoplastic skin diseases such as cutaneous T cell lymphoma, among others. Previous work has addressed the use of pro- and pre-biotics to protect against UVR through anti-oxidative, anti-inflammatory, anti-aging, anti-carcinogenic and/or pro-and contra-melanogenic properties. Herein, we discuss and share perspectives of the potential benefits of novel treatment strategies using microbes and pro- and pre-biotics as modulators of the skin response to UVR, and how they could act both for protection against UVR-induced skin damage and as enhancers of the UVR-driven therapeutic effects on the skin. View Full-Text
Keywords: ultraviolet radiation; skin inflammation; skin microbiome; probiotics; prebiotics; photobiology; photoimmunology ultraviolet radiation; skin inflammation; skin microbiome; probiotics; prebiotics; photobiology; photoimmunology
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Patra, V.; Gallais Sérézal, I.; Wolf, P. Potential of Skin Microbiome, Pro- and/or Pre-Biotics to Affect Local Cutaneous Responses to UV Exposure. Nutrients 2020, 12, 1795.

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