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Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability

1
Eurecat, Technology Centre of Catalunya, Nutrition and Health Unit, 43204 Reus, Spain
2
Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Campus Sescelades, 43007 Tarragona, Spain
3
Eurecat, Technology Centre of Catalunya, Biotechnology Area and Technological Unit of Nutrition and Health, 43204 Reus, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work as first authors.
Nutrients 2020, 12(5), 1488; https://doi.org/10.3390/nu12051488
Received: 27 March 2020 / Revised: 7 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue Diet, Gut Microbiota and Metabolic Disorders)
Recently, hesperidin, a flavonone mainly present in citrus fruits, has emerged as a new potential therapeutic agent able to modulate several cardiovascular diseases (CVDs) risk factors. Animal and in vitro studies demonstrate beneficial effects of hesperidin and its derived compounds on CVD risk factors. Thus, hesperidin has shown glucose-lowering and anti-inflammatory properties in diabetic models, dyslipidemia-, atherosclerosis-, and obesity-preventing effects in CVDs and obese models, and antihypertensive and antioxidant effects in hypertensive models. However, there is still controversy about whether hesperidin could contribute to ameliorate glucose homeostasis, lipid profile, adiposity, and blood pressure in humans, as evidenced by several clinical trials reporting no effects of treatments with this flavanone or with orange juice on these cardiovascular parameters. In this review, we focus on hesperidin’s beneficial effects on CVD risk factors, paying special attention to the high interindividual variability in response to hesperidin-based acute and chronic interventions, which can be partly attributed to differences in gut microbiota. Based on the current evidence, we suggest that some of hesperidin’s contradictory effects in human trials are partly due to the interindividual hesperidin variability in its bioavailability, which in turn is highly dependent on the α-rhamnosidase activity and gut microbiota composition. View Full-Text
Keywords: cardiovascular diseases; hesperidin; hesperetin; gut microbiota; dysbiosis; bioavailability cardiovascular diseases; hesperidin; hesperetin; gut microbiota; dysbiosis; bioavailability
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MDPI and ACS Style

Mas-Capdevila, A.; Teichenne, J.; Domenech-Coca, C.; Caimari, A.; Del Bas, J.M; Escoté, X.; Crescenti, A. Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability. Nutrients 2020, 12, 1488. https://doi.org/10.3390/nu12051488

AMA Style

Mas-Capdevila A, Teichenne J, Domenech-Coca C, Caimari A, Del Bas JM, Escoté X, Crescenti A. Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability. Nutrients. 2020; 12(5):1488. https://doi.org/10.3390/nu12051488

Chicago/Turabian Style

Mas-Capdevila, Anna; Teichenne, Joan; Domenech-Coca, Cristina; Caimari, Antoni; Del Bas, Josep M; Escoté, Xavier; Crescenti, Anna. 2020. "Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability" Nutrients 12, no. 5: 1488. https://doi.org/10.3390/nu12051488

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