Next Article in Journal
The Effects of Two Intervention Strategies to Reduce the Intake of Salt and the Sodium-To-Potassium Ratio on Cardiovascular Risk Factors. A 4-Month Randomised Controlled Study among Healthy Families
Previous Article in Journal
Vitamin D Deficiency and Oral Health: A Comprehensive Review
Article

Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer

1
Department of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
2
Clinical Research Management Center, Nagoya City University Hospital, Aichi 467-8602, Japan
3
Division of Nutritional Management, Osaka University Hospital, Osaka 565-0871, Japan
4
Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
5
United Graduate School of Child Development, Osaka University, Osaka 565-0871, Japan
6
Department of Respiratory Medicine and Hematology, Hyogo College of Medicine, Hyogo 663-8501, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1473; https://doi.org/10.3390/nu12051473
Received: 22 April 2020 / Revised: 9 May 2020 / Accepted: 15 May 2020 / Published: 19 May 2020
(This article belongs to the Section Clinical Nutrition)
A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study of a new ketogenic diet regimen in patients with different types of stage IV cancer. Carbohydrates were restricted to 10 g/day during week one, 20 g/day from week two for three months, and 30 g/day thereafter. A total of 55 patients participated in the study, and data from 37 patients administered the ketogenic diet for three months were analyzed. No severe adverse events associated with the diet were observed. Total ketone bodies increased significantly, and both fasting blood sugar and insulin levels were suppressed significantly for three months after completion of the study. Five patients showed a partial response on Positron emission tomography–computed tomography (PET-CT) at three months. Three and seven patients showed complete and partial responses, respectively at one year. Median survival was 32.2 (maximum: 80.1) months, and the three-year survival rate was 44.5%. After three months on the ketogenic diet, the serum Alb, BS, and CRP (ABC) score could be used to stratify the patients into groups with significantly different survival rates (p < 0.001, log-rank test). Our ketogenic diet regimen is considered to be a promising support therapy for patients with different types of advanced cancer. View Full-Text
Keywords: cancer; ketogenic diet; PET-CT cancer; ketogenic diet; PET-CT
Show Figures

Figure 1

MDPI and ACS Style

Hagihara, K.; Kajimoto, K.; Osaga, S.; Nagai, N.; Shimosegawa, E.; Nakata, H.; Saito, H.; Nakano, M.; Takeuchi, M.; Kanki, H.; Kagitani-Shimono, K.; Kijima, T. Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer. Nutrients 2020, 12, 1473. https://doi.org/10.3390/nu12051473

AMA Style

Hagihara K, Kajimoto K, Osaga S, Nagai N, Shimosegawa E, Nakata H, Saito H, Nakano M, Takeuchi M, Kanki H, Kagitani-Shimono K, Kijima T. Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer. Nutrients. 2020; 12(5):1473. https://doi.org/10.3390/nu12051473

Chicago/Turabian Style

Hagihara, Keisuke, Katsufumi Kajimoto, Satoshi Osaga, Naoko Nagai, Eku Shimosegawa, Hideyuki Nakata, Hitomi Saito, Mai Nakano, Mariko Takeuchi, Hideaki Kanki, Kuriko Kagitani-Shimono, and Takashi Kijima. 2020. "Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer" Nutrients 12, no. 5: 1473. https://doi.org/10.3390/nu12051473

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop